Stage of breast cancer at diagnosis in New Zealand: impacts of socio-demographic factors, breast cancer screening and biology

Seneviratne, Sanjeewa; Lawrenson, Ross; Harvey, Vernon; Ramsaroop, Reena; Elwood, Mark; Scott, Nina; Sarfati, Diana; Campbell, Ian

doi:10.1186/s12885-016-2177-5

Table 2 Multivariate analysis for factors associated with advanced and metastatic breast cancer versus early breast cancer at diagnosis, 2000–2013

From: Stage of breast cancer at diagnosis in New Zealand: impacts of socio-demographic factors, breast cancer screening and biology

Characteristic	Univariate						Adjusted
Characteristic	OR	Advanced 95% CI	p	OR	Metastatic 95% CI	p	OR	Advanced 95% CI	p	OR	Metastatic 95% CI	p
Age
<40	1.70	1.43–2.02		1.63	1.15–2.31		1.10	0.92–1.32		1.03	0.70–1.50
40–49	Ref		0.000	Ref		0.000	Ref		0.000	Ref		0.021
50–59	0.76	0.67–0.86		0.81	0.62–1.05		1.10	0.96–1.26		1.24	0.93–1.65
60–69	0.59	0.51–0.67		0.78	0.60–1.03		0.90	0.78–1.05		1.19	0.88–1.61
70–79	0.84	0.72–0.98		1.51	1.15–1.99		0.85	0.72–1.00		1.50	1.10–2.04
80+	0.98	0.83–1.16		1.72	1.29–2.32		0.76	0.63–0.91		0.84	0.59–1.21
Year of diagnosis
2000–2003	Ref		0.068	Ref		0.079	Ref		0.311	Ref		0.042
2004–2006	1.09	0.96–1.24		1.22	0.94–1.59		0.93	0.80–1.08		1.19	0.87–1.64
2007–2009	1.07	0.94–1.21		1.37	1.07–1.76		0.95	0.81–1.12		1.51	1.10–2.07
2010–2013	0.94	0.83–1.06		1.29	1.01–1.65		0.87	0.75–1.02		1.44	1.06–1.96
Region
Auckland	Ref		0.004	Ref		0.000	Ref		0.741	Ref		0.903
Waikato	1.16	1.05–1.29		1.43	1.18–1.72		1.03	0.85–1.24		0.98	0.68–1.42
Ethnicity
NZ European	Ref			Ref			Ref			Ref
Maori	1.58	1.37–1.82	0.000	2.14	1.68–2.73	0.000	1.27	1.08–1.49	0.004	1.86	1.39–2.49	0.000
Pacific	2.27	1.95–2.65	0.000	3.38	2.64–4.35	0.000	1.72	1.43–2.06	0.000	2.81	2.03–3.87	0.000
Asian	0.96	0.81–1.14	0.639	0.88	0.61–1.26	0.475	0.81	0.67–0.98	0.026	0.90	0.61–1.33	0.609
Other	0.76	0.55–1.04	0.755	1.10	0.64–1.90	0.737	0.87	0.62–1.23	0.426	1.56	0.86–2.83	0.146
Unknown	0.31	0.17–0.60	0.000	0.15	0.02–1.05	0.056	0.37	0.19–0.72	0.003	0.22	0.03–1.63	0.139
Deprivation
1–2	Ref		0.000	Ref		0.000	Ref		0.000	Ref		0.017
3–4	0.99	0.85–1.16		1.08	0.78–1.48		0.96	0.81–1.14		0.84	0.59–1.19
5–6	1.09	0.95–1.26		1.21	0.91–1.63		1.05	0.90–1.23		0.99	0.71–1.36
7–8	1.45	1.26–1.66		1.79	1.36–2.36		1.31	1.12–1.53		1.40	1.02–1.92
9–10	1.57	1.37–1.80		2.18	1.67–2.84		1.28	1.09–1.51		1.40	1.01–1.92
Unknown	0.80	0.46–1.36		1.26	0.50–3.18		0.79	0.14–4.47		0.94	0.01–109
Urban rural
Main urban	Ref		0.009	Ref		0.001	Ref		0.981	Ref		0.004
Other urban	0.91	0.74–1.10		1.40	1.01–1.93		1.03	0.83–1.29		2.00	1.37–2.92
Rural	1.16	1.04–1.30		1.48	1.21–1.81		1.01	0.82–1.25		1.22	0.83–1.82
Unknown	0.66	0.40–1.11		0.90	0.37–2.28		0.78	0.15–4.18		0.40	0.01–46.1
Mode of detection
Screen	Ref		0.000	Ref		0.000	Ref		0.000	Ref		0.000
Non−screen	4.83	4.28–5.44		8.18	6.13–10.9		3.79	3.33–4.34		6.03	4.41–8.24
ER/PR status
ER/PR Positive	Ref		0.000	Ref		0.000	Ref		0.070	Ref		0.620
ER & PR Negative	1.73	1.55–1.92		1.92	1.58–2.34		1.13	0.99–1.28		1.06	0.83–1.36
Unknown	1.60	1.23–2.08		5.45	4.00–7.45		1.50	1.06–2.14		1.12	0.71–1.79
Grade
Grade I	Ref		0.000	Ref		0.000	Ref		0.000	Ref		0.000
Grade II	3.73	3.13–4.44		3.88	2.56–5.88		2.85	2.38–3.40		2.72	1.78–4.14
Grade III	7.00	5.88–8.35		7.76	5.12–11.7		4.13	3.30–5.00		3.85	2.47–5.99
Unknown	13.6	10.8–16.9		56.2	36.8–85.7		12.7	9.82–16.4		49.6	31.2–79.1
HER-2 status
Negative	Ref		0.000	Ref		0.000	Ref		0.000	Ref		0.000
Equivocal	0.83	0.57–1.22		0.61	0.25–1.49		0.73	0.48–1.10		0.46	0.18–1.19
Positive	2.36	2.10–2.66		2.65	2.13–3.28		1.57	1.38–1.79		1.80	1.41–2.31
Unknown	0.84	0.75–0.94		1.18	0.96–1.45		0.63	0.54–0.74		0.63	0.45–0.87

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