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Table 2 Multivariate analysis for factors associated with advanced and metastatic breast cancer versus early breast cancer at diagnosis, 2000–2013

From: Stage of breast cancer at diagnosis in New Zealand: impacts of socio-demographic factors, breast cancer screening and biology

Characteristic Univariate Adjusted
OR Advanced 95% CI p OR Metastatic 95% CI p OR Advanced 95% CI p OR Metastatic 95% CI p
Age  
  <40 1.70 1.43–2.02   1.63 1.15–2.31   1.10 0.92–1.32   1.03 0.70–1.50  
  40–49 Ref   0.000 Ref   0.000 Ref   0.000 Ref   0.021
  50–59 0.76 0.67–0.86   0.81 0.62–1.05   1.10 0.96–1.26   1.24 0.93–1.65  
  60–69 0.59 0.51–0.67   0.78 0.60–1.03   0.90 0.78–1.05   1.19 0.88–1.61  
  70–79 0.84 0.72–0.98   1.51 1.15–1.99   0.85 0.72–1.00   1.50 1.10–2.04  
  80+ 0.98 0.83–1.16   1.72 1.29–2.32   0.76 0.63–0.91   0.84 0.59–1.21  
Year of diagnosis
  2000–2003 Ref   0.068 Ref   0.079 Ref   0.311 Ref   0.042
  2004–2006 1.09 0.96–1.24   1.22 0.94–1.59   0.93 0.80–1.08   1.19 0.87–1.64  
  2007–2009 1.07 0.94–1.21   1.37 1.07–1.76   0.95 0.81–1.12   1.51 1.10–2.07  
  2010–2013 0.94 0.83–1.06   1.29 1.01–1.65   0.87 0.75–1.02   1.44 1.06–1.96  
Region             
  Auckland Ref   0.004 Ref   0.000 Ref   0.741 Ref   0.903
  Waikato 1.16 1.05–1.29   1.43 1.18–1.72   1.03 0.85–1.24   0.98 0.68–1.42  
Ethnicity
  NZ European Ref    Ref    Ref    Ref   
  Maori 1.58 1.37–1.82 0.000 2.14 1.68–2.73 0.000 1.27 1.08–1.49 0.004 1.86 1.39–2.49 0.000
  Pacific 2.27 1.95–2.65 0.000 3.38 2.64–4.35 0.000 1.72 1.43–2.06 0.000 2.81 2.03–3.87 0.000
  Asian 0.96 0.81–1.14 0.639 0.88 0.61–1.26 0.475 0.81 0.67–0.98 0.026 0.90 0.61–1.33 0.609
  Other 0.76 0.55–1.04 0.755 1.10 0.64–1.90 0.737 0.87 0.62–1.23 0.426 1.56 0.86–2.83 0.146
  Unknown 0.31 0.17–0.60 0.000 0.15 0.02–1.05 0.056 0.37 0.19–0.72 0.003 0.22 0.03–1.63 0.139
Deprivation
  1–2 Ref   0.000 Ref   0.000 Ref   0.000 Ref   0.017
  3–4 0.99 0.85–1.16   1.08 0.78–1.48   0.96 0.81–1.14   0.84 0.59–1.19  
  5–6 1.09 0.95–1.26   1.21 0.91–1.63   1.05 0.90–1.23   0.99 0.71–1.36  
  7–8 1.45 1.26–1.66   1.79 1.36–2.36   1.31 1.12–1.53   1.40 1.02–1.92  
  9–10 1.57 1.37–1.80   2.18 1.67–2.84   1.28 1.09–1.51   1.40 1.01–1.92  
  Unknown 0.80 0.46–1.36   1.26 0.50–3.18   0.79 0.14–4.47   0.94 0.01–109  
Urban rural
  Main urban Ref   0.009 Ref   0.001 Ref   0.981 Ref   0.004
  Other urban 0.91 0.74–1.10   1.40 1.01–1.93   1.03 0.83–1.29   2.00 1.37–2.92  
  Rural 1.16 1.04–1.30   1.48 1.21–1.81   1.01 0.82–1.25   1.22 0.83–1.82  
  Unknown 0.66 0.40–1.11   0.90 0.37–2.28   0.78 0.15–4.18   0.40 0.01–46.1  
Mode of detection
  Screen Ref   0.000 Ref   0.000 Ref   0.000 Ref   0.000
  Non−screen 4.83 4.28–5.44   8.18 6.13–10.9   3.79 3.33–4.34   6.03 4.41–8.24  
ER/PR status
  ER/PR Positive Ref   0.000 Ref   0.000 Ref   0.070 Ref   0.620
  ER & PR Negative 1.73 1.55–1.92   1.92 1.58–2.34   1.13 0.99–1.28   1.06 0.83–1.36  
  Unknown 1.60 1.23–2.08   5.45 4.00–7.45   1.50 1.06–2.14   1.12 0.71–1.79  
Grade
  Grade I Ref   0.000 Ref   0.000 Ref   0.000 Ref   0.000
  Grade II 3.73 3.13–4.44   3.88 2.56–5.88   2.85 2.38–3.40   2.72 1.78–4.14  
  Grade III 7.00 5.88–8.35   7.76 5.12–11.7   4.13 3.30–5.00   3.85 2.47–5.99  
  Unknown 13.6 10.8–16.9   56.2 36.8–85.7   12.7 9.82–16.4   49.6 31.2–79.1  
HER-2 status
  Negative Ref   0.000 Ref   0.000 Ref   0.000 Ref   0.000
  Equivocal 0.83 0.57–1.22   0.61 0.25–1.49   0.73 0.48–1.10   0.46 0.18–1.19  
  Positive 2.36 2.10–2.66   2.65 2.13–3.28   1.57 1.38–1.79   1.80 1.41–2.31  
  Unknown 0.84 0.75–0.94   1.18 0.96–1.45   0.63 0.54–0.74   0.63 0.45–0.87