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Table 1 Baseline characteristics

From: A phase 1b study of Selumetinib in combination with Cisplatin and Gemcitabine in advanced or metastatic biliary tract cancer: the ABC-04 study

Variables

Number of patients (%)

Age (years)

 Median (IQR)

65 (61 to 68)

Sex

 Female

9 (69 %)

 Male

4 (31 %)

Primary site

 Gall bladder

3 (23 %)

 Bile duct

9 (69 %)

 Ampulla

1 (8 %)

ECOG PS

 0

9 (69 %)

 1

4 (31 %)

T-stage

 T1

1 (8 %)

 T2

0 (0 %)

 T3

8 (62 %)

 T4

1 (8 %)

 TX

3 (23 %)

N-stage

 N0

2 (15 %)

 N1

5 (38 %)

 N2

1 (8 %)

 NX

5 (38 %)

M-stage

 M0

1 (8 %)

 M1a

10 (77 %)

 MX

2 (15 %)

Tumour differentiation

 Well/Moderately differentiated

6 (46 %)

 Poorly differentiated

6 (46 %)

 Not specified

1 (8 %)

Previous treatment

 

 None

5 (38 %)

 Chemotherapy

0 (0 %)

 Surgery

8 (62 %)

 Radiotherapy

0 (0 %)

 Other

0 (0 %)

 2+ types

0 (0 %)

 Biliary Stent Insertions

7 (54 %)

  1. aSites of metastasis: 8 patients had liver metastases, 3 had peritoneum, 2 had lung. Two patients had other metastasis: one had small bowel and the other had coeliac lymph node positive gastric lymph node