Table 4 Acute toxicities in high-risk oral cavity cancer patients treated with postoperative helical tomotherapy (HT, image-guided radiotherapy, IGRT) and intensity-modulated radiotherapy (IMRT, non- image-guided radiotherapy, non-IGRT) with or without concurrent chemoradiation therapy (CCRT)

^aXerostomia (Acute)

Gr.1

54 (68.4 %)

54 (74.0 %)

0.445

Gr.2

25 (31.6 %)

19 (26.0 %)

Gr.3

0

0

Gr.4

0

0

Gr.5

0

0

Mucositis

Gr.1

7 (8.9 %)

4 (5.5 %)

0.627

Gr.2

49 (62.0 %)

44 (60.3 %)

Gr.3

23 (29.1 %)

25 (34.2 %)

Gr.4

0

0

Gr.5

0

0

Dermatitis

Gr.1

33 (41.8 %)

33 (45.2 %)

0.180

Gr.2

30 (47.6 %)

33 (45.2 %)

Gr.3

16 (20.3 %)

7 (9.6 %)

Gr.4

0

0

Gr.5

0

0

Body weight loss

Gr.1

51 (64.6 %)

62 (84.9 %)

0.004

Gr.2

27 (34.2 %)

11 (15.1 %)

Gr.3

1 (1.3 %)

0

Gr.4

0

0

Gr.5

0

0

Dysphagia

Gr.1

53 (67.1 %)

55 (75.3 %)

0.472

Gr.2

11 (13.9 %)

9 (12.3 %)

Gr.3

15 (19.0 %)

9 (12.3 %)

Gr.4

0

0

Gr.5

0

0

Fistula formation or superficial cases of skin dehiscence

Yes

1 (1.3 %)

3 (4.1 %)

0.351

No

78 (98.7 %)

70 (95.9 %)

Anemia

Normal

11 (13.9 %)

15 (20.5 %)

0.507

Gr.1

58 (73.4 %)

51 (69.9 %)

Gr.2

10(12.7 %)

7 (9.6 %)

Gr.3

0

0

Gr.4

0

0

Gr.5

0

0

Leucopenia

Normal

14 (17.7 %)

24 (32.9 %)

0.007

Gr.1

49 (62.0 %)

25 (34.2 %)

Gr.2

9 (11.4 %)

17 (23.3 %)

Gr.3

5 (6.3 %)

6 (8.2 %)

Gr.4

2 (2.5 %)

1 (1.4 %)

Gr.5

0

0

Thrombocytopenia

Normal

15 (19.0 %)

31 (42.5 %)

0.003

Gr.1

59 (74.7 %)

41 (56.2 %)

Gr.2

3 (3.8 %)

1 (1.4 %)

Gr.3

2 (2.5 %)

0

Gr.4

0

0

Gr.5

0

0