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Table 3 The 5-year overall survival rate and local-progression free survival rate of postoperative oral cavity cancer patients under prognostic factors treated with helical tomotherapy (HT, image-guided radiotherapy, IGRT) and intensity-modulated radiotherapy (IMRT, non- image-guided radiotherapy, non-IGRT)

From: Impact of postoperative daily image-guided intensity-modulated radiotherapy on overall and local progression-free survival in patients with oral cavity cancer

  5-year OS 5-year LPFS
Prognostic factors Modality 95 % CI p value Modality 95 % CI p value
  HT IMRT    HT IMRT   
Resection-margin 84.0 % 57.7 % 0.52 to 0.68, 0.008 92.5 % 28.6 % 0.51 to 0.77 0.006
ECE 76.6 % 31.7 % 0.39 to 0.65, 0.007 54.0 % 64.1 % 0.39 to 0.65 0.942
PNI 79.3 % 35.2 % 0.15 to 0.97 0.005 82.3 % 43.9 % 0.28 to 0.85 0.003
LVSI 77.0 % 50.0 % 0.49 to 0.64 0.012 78.8 % 0.0 % 0.54 to 0.74 0.001
Two or more positive lymph nodes 74.0 % 40.3 % 0.41 to 0.61 0.010 77.0 % 26.2 % 0.29 to 0.85 0.003
T3,4 72.8 % 38.7 % 0.39 to 0.73 0.017 79.5 % 39.8 % 0.25 to 1.02 0.005
  Hazard ratio (HR)a 95 % CI P value Hazard ratio (HR)a 95 % CI P value
Modality HT vs IMRT 0.32 0.15 to 0.67 0.002 0.21 0.08 to 0.59 0.003
  1. Abbreviations: CI, confidence interval; ECE extracapsular spread, HT helical tomotherapy, IMRT intensity-modulated radiotherapy, LPFS local progression-free survival rate, LVSI lymphovascular space involvement, OS overall survival rate, PNI perineural invasion
  2. aHazard ratios were derived from Cox proportional hazards regression after adjusting ECE, PNI, LVSI, two or more positive lymph nodes and T3,4 variables
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