Impact of postoperative daily image-guided intensity-modulated radiotherapy on overall and local progression-free survival in patients with oral cavity cancer

Table 3 The 5-year overall survival rate and local-progression free survival rate of postoperative oral cavity cancer patients under prognostic factors treated with helical tomotherapy (HT, image-guided radiotherapy, IGRT) and intensity-modulated radiotherapy (IMRT, non- image-guided radiotherapy, non-IGRT)

	5-year OS				5-year LPFS
Prognostic factors	Modality		95 % CI	p value	Modality		95 % CI	p value
	HT	IMRT			HT	IMRT
Resection-margin	84.0 %	57.7 %	0.52 to 0.68,	0.008	92.5 %	28.6 %	0.51 to 0.77	0.006
ECE	76.6 %	31.7 %	0.39 to 0.65,	0.007	54.0 %	64.1 %	0.39 to 0.65	0.942
PNI	79.3 %	35.2 %	0.15 to 0.97	0.005	82.3 %	43.9 %	0.28 to 0.85	0.003
LVSI	77.0 %	50.0 %	0.49 to 0.64	0.012	78.8 %	0.0 %	0.54 to 0.74	0.001
Two or more positive lymph nodes	74.0 %	40.3 %	0.41 to 0.61	0.010	77.0 %	26.2 %	0.29 to 0.85	0.003
T3,4	72.8 %	38.7 %	0.39 to 0.73	0.017	79.5 %	39.8 %	0.25 to 1.02	0.005
	Hazard ratio (HR)^a		95 % CI	P value	Hazard ratio (HR)^a		95 % CI	P value
Modality HT vs IMRT	0.32		0.15 to 0.67	0.002	0.21		0.08 to 0.59	0.003

Abbreviations: CI, confidence interval; ECE extracapsular spread, HT helical tomotherapy, IMRT intensity-modulated radiotherapy, LPFS local progression-free survival rate, LVSI lymphovascular space involvement, OS overall survival rate, PNI perineural invasion
^aHazard ratios were derived from Cox proportional hazards regression after adjusting ECE, PNI, LVSI, two or more positive lymph nodes and T3,4 variables

ISSN: 1471-2407