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Fig. 1 | BMC Cancer

Fig. 1

From: Combination of metformin and 5-aminosalicylic acid cooperates to decrease proliferation and induce apoptosis in colorectal cancer cell lines

Fig. 1

Effect of different concentrations of (a) 5-ASA and (b) Metformin on surviving fractions of Caco-2 and HCT-116 cells treated for 48 h. c Surviving fraction of Caco-2 and HCT-116 cells after treatment with subIC50 concentrations of metformin, 5-ASA and a combination of both for 48 h. All data are expressed as mean ± SD of 3 separate experiments performed in triplicates. The statistical significance of the results was analyzed using one way ANOVA followed by Tukey-Kramer multiple comparison test. a Significantly different from control, b from metformin and c from 5-ASA (P <0.05)

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