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Table 4 Predictive value of the 8-gene CTC profile in uni- and multivariate analysis

From: An 8-gene mRNA expression profile in circulating tumor cells predicts response to aromatase inhibitors in metastatic breast cancer patients

Factor of base model

Univariate analysis

Multivariate analysis

 

PFS

PFS

 

HR

95 % CI

P

HR

95 % CI

P

<5 vs. ≥5 CTCs at baseline

1,11

0.57–2.15

0,753

1,31

0.65–2.62

0.455

Disease-free intervala

1,09

0.74–1.61

0,653

0,95

0.62–1.43

0.790

Dominant site of relapseb

1,34

0.69–2.58

0,384

1,11

0.56–2.18

0.768

8-gene CTC profile

4,40

2.17–8.92

<0.001

4,59

2.16–9.75

<0.001

  1. aDefined as the time between primary surgery and CTC sampling and analyzed in 3 groups: ≤5 years (N = 12), >5 years (N = 21) and metastatic disease upon diagnosis (N = 12)
  2. bDivided into non-visceral vs. visceral metastases