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Table 4 Predictive value of the 8-gene CTC profile in uni- and multivariate analysis

From: An 8-gene mRNA expression profile in circulating tumor cells predicts response to aromatase inhibitors in metastatic breast cancer patients

Factor of base model Univariate analysis Multivariate analysis
  PFS PFS
  HR 95 % CI P HR 95 % CI P
<5 vs. ≥5 CTCs at baseline 1,11 0.57–2.15 0,753 1,31 0.65–2.62 0.455
Disease-free intervala 1,09 0.74–1.61 0,653 0,95 0.62–1.43 0.790
Dominant site of relapseb 1,34 0.69–2.58 0,384 1,11 0.56–2.18 0.768
8-gene CTC profile 4,40 2.17–8.92 <0.001 4,59 2.16–9.75 <0.001
  1. aDefined as the time between primary surgery and CTC sampling and analyzed in 3 groups: ≤5 years (N = 12), >5 years (N = 21) and metastatic disease upon diagnosis (N = 12)
  2. bDivided into non-visceral vs. visceral metastases