Fig. 2

Unsupervised hierarchical cluster analysis comparing the 8-gene CTC predictor in 45 MBC patients treated with first-line AI therapy. Each horizontal row represents a gene, and each vertical column corresponds to a sample. Red color indicates a mRNA expression level above the median level, black color indicates a median expression level, and green color indicates an expression level below the median level of the assay as measured in all 45 samples. The number of CTCs as established by the CellSearch Epithelial Kit is depicted below the figure. Blue: good responder; red: poor responder. CTC count: blue: <5 CTCs; red: ≥5 CTCs