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Fig. 4 | BMC Cancer

Fig. 4

From: BCORL1 is an independent prognostic marker and contributes to cell migration and invasion in human hepatocellular carcinoma

Fig. 4

BCORL1 is inversely correlated with E-cadherin in HCC. a The positive expression rate of E-cadherin in BCORL1 positive HCC specimens was significantly lower than that in BCORL1 negative cases. * P < 0.05 by Pearson chi-squared test. b Representative immunohistochemical staining showed weak staining of E-cadherin (III) in BCORL1 positive-expressing tumor (I) and strong staining of E-cadherin (IV) in BCORL1 negative-expressing tumor (II). Scale bar: 50 μm. c qRT-PCR analysis of E-cadherin mRNA expression in HCCLM3 cells with BCORL1 siRNA or scrambled siRNA transfection. * P < 0.05 by t test, n = 3. d BCORL1 knockdown increased the level of E-cadherin protein and reduced the expression of vimentin and N-cadherin in HCCLM3 cells. * P < 0.05 by t test, n = 6. e qRT-PCR analysis of E-cadherin mRNA expression in Hep3B cells with BCORL1or empty vector (EV) lentiviruses infection. * P < 0.05 by t test, n = 3. f BCORL1 overexpression decreased the level of E-cadherin protein and up-regulated the expression of vimentin and N-cadherin in Hep3B cells. * P < 0.05 by t test, n = 6

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