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Table 2 The 13 keys parameters for statistical HRQoL analysis assessed as “yes” if the authors specified the parameter, “not clear” it was not clear and “no” if the authors didn’t specify the parameter

From: Methodology of health-related quality of life analysis in phase III advanced non-small-cell lung cancer clinical trials: a critical review

  Yes, n (%) Not clear, n (%) No, n (%)
Targeted dimensions 13 (48.1) 0 14 (51.9)
HRQoL hypothesis 2 (7.4) 0 25 (92.6)
Procedure to control the type I error 1 (3.7) 1 (3.7) 25 (92.6)
Minimal clinically important difference 9 (33.3) 1 (3.7) 17 (63)
Study population 3 (11.1) 3 (11.1) 21 (77.8)
Number of HRQoL data at subsequent time points 7 (25.9) 6 (22.2) 14 (51.9)
HRQoL scores at baseline for each group and each dimension 6 (22.2) 2 (7.4) 19 (70.4)
Profile of missing data at baseline 1 (3.7) 2 (7.4) 24 (88.9)
Statistical approaches for dealing with missing data 5 (18.5) 0 22 (81.5)
Statistical approach for HRQoL analysis 14 (51.9) 1 (3.7) 12 (44.4)
MCID taken into account in the statistical analysis 7 (25.9) 2 (7.4) 18 (66.7)
Multivariate analysis 1 (3.7) 0 26 (96.4)
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