Skip to main content

Table 1 Clinicopathological features of primary colorectal carcinomas of patients from Ontario and Newfoundland

From: Promoter methylation of ITF2, but not APC, is associated with microsatellite instability in two populations of colorectal cancer patients

  No. of cases (%)
  Ontario Newfoundland
  MSS MSI-H MSS MSI-H
Cases of primary colorectal carcinoma 165 165 51 51
Mean age (±SDa) 59.9 (9.3) 60.1 (9.8) 58.3 (10.2) 58.4 (10.2)
Age     
 <50 19 (11.5) 28 (17.0) 11 (21.6) 10 (19.6)
 50+ 146 (88.5) 137 (83.0) 40 (78.4) 41 (80.4)
Sex     
 Male 74 (44.8) 74 (44.8) 26 (51.0) 26 (51.0)
 Female 91 (55.2) 91 (55.2) 25 (49.0) 25 (49.0)
TNM Stage     
 1 38 (23.0) 38 (23.0) 12 (23.5) 11 (21.6)
 2 84 (50.9) 85 (51.5) 26 (51.0) 27 (52.9)
 3 34 (20.6) 39 (23.6) 10 (19.6) 12 (23.5)
 4 9 (5.5) 3 (1.8) 3 (5.9) 1 (2.0)
Histological Grade     
 Low 16 (9.7) 10 (6.1) 4 (7.8) 7 (13.7)
 Moderate 123 (74.5) 45 (27.3) 37 (72.6) 36 (70.6)
 High 13 (7.9) 20 (12.1) 8 (15.7) 8 (15.7)
 Unavailable 13 (7.9) 90 (54.5) 2 (3.9)  
Locationb     
 Distal 108 (65.5) 15 (9.1) 37 (72.5) 9 (17.6)
 Proximal 51 (30.9) 63 (38.2) 14 (27.5) 42 (82.4)
 Unavailable 6 (3.6) 87 (52.7)   
Histological Typec     
 Non-Mucinous 143 (86.7) 107 (64.8) 46 (90.2) 42 (82.4)
 Mucinous 19 (11.5) 53 (32.1) 5 (9.8) 9 (17.6)
 Unavailable 3 (1.8) 5 (3.0)   
MMR Protein Status     
 Intact 148 (89.7) 26 (15.8) 50 (98.0) 4 (7.8)
 Deficient 4 (2.4) 136 (82.4) 0 (0.0) 46 (90.2)
 Unavailable 13 (7.9) 3 (1.8) 1 (2.0) 1 (2.0)
MMR Germline Mutation     
 No 164 (99.4) 124 (75.2) 51 (100.0) 39 (76.5)
 Yes 1 (0.6) 41 (24.8) 0 (0.0) 12 (23.5)
MLH1 Methylation     
 Unmethylated 159 (96.4) 87 (52.7) 36 (70.6) 23 (45.1)
 Methylated 5 (3.0) 78 (47.3) 1 (2.0) 28 (54.9)
 Unavailable 1 (0.6)   14 (27.4)  
BRAF V600E Mutation     
 No 146 (88.5) 95 (57.6) 46 (90.2) 25 (49.0)
 Yes 15 (9.1) 66 (40.0) 2 (3.9) 20 (39.2)
 Unavailable 4 (2.4) 4 (2.4) 3 (5.9) 6 (11.8)
CIMP Status     
 Negative 133 (80.6) 79 (47.9)   
 Positive 10 (6.1) 63 (38.2)   
 Unavailable 22 (13.3) 23 (13.9) 51 (100.0) 51 (100.0)
Survival Status     
 Alive 100 (60.6)‬ 99 (60.0) 45 (88.2) 49 (96.1)
 Deceased 65 (39.4) 66 (40.0) 6 (11.8) 2 (3.9)
ITF2 Methylation     
 Unmethylated 122 (73.9) 95 (57.6) 36 (70.6) 22 (43.1)
 Methylated 43 (26.1) 70 (42.4) 15 (29.4) 29 (56.9)
APC Methylation     
 Unmethylated 112 (67.9) 103 (67.9) 33 (64.7) 28 (54.9)
 Methylated 53 (32.1) 62 (37.6) 18 (35.3) 23 (45.1)
  1. aStandard Deviation
  2. bProximal tumor location includes lesions up to and including the splenic flexure
  3. cMucinous histology includes the presence of any mucin within the tumor stroma