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Table 1 Clinicopathological features of primary colorectal carcinomas of patients from Ontario and Newfoundland

From: Promoter methylation of ITF2, but not APC, is associated with microsatellite instability in two populations of colorectal cancer patients

 

No. of cases (%)

 

Ontario

Newfoundland

 

MSS

MSI-H

MSS

MSI-H

Cases of primary colorectal carcinoma

165

165

51

51

Mean age (±SDa)

59.9 (9.3)

60.1 (9.8)

58.3 (10.2)

58.4 (10.2)

Age

    

 <50

19 (11.5)

28 (17.0)

11 (21.6)

10 (19.6)

 50+

146 (88.5)

137 (83.0)

40 (78.4)

41 (80.4)

Sex

    

 Male

74 (44.8)

74 (44.8)

26 (51.0)

26 (51.0)

 Female

91 (55.2)

91 (55.2)

25 (49.0)

25 (49.0)

TNM Stage

    

 1

38 (23.0)

38 (23.0)

12 (23.5)

11 (21.6)

 2

84 (50.9)

85 (51.5)

26 (51.0)

27 (52.9)

 3

34 (20.6)

39 (23.6)

10 (19.6)

12 (23.5)

 4

9 (5.5)

3 (1.8)

3 (5.9)

1 (2.0)

Histological Grade

    

 Low

16 (9.7)

10 (6.1)

4 (7.8)

7 (13.7)

 Moderate

123 (74.5)

45 (27.3)

37 (72.6)

36 (70.6)

 High

13 (7.9)

20 (12.1)

8 (15.7)

8 (15.7)

 Unavailable

13 (7.9)

90 (54.5)

2 (3.9)

 

Locationb

    

 Distal

108 (65.5)

15 (9.1)

37 (72.5)

9 (17.6)

 Proximal

51 (30.9)

63 (38.2)

14 (27.5)

42 (82.4)

 Unavailable

6 (3.6)

87 (52.7)

  

Histological Typec

    

 Non-Mucinous

143 (86.7)

107 (64.8)

46 (90.2)

42 (82.4)

 Mucinous

19 (11.5)

53 (32.1)

5 (9.8)

9 (17.6)

 Unavailable

3 (1.8)

5 (3.0)

  

MMR Protein Status

    

 Intact

148 (89.7)

26 (15.8)

50 (98.0)

4 (7.8)

 Deficient

4 (2.4)

136 (82.4)

0 (0.0)

46 (90.2)

 Unavailable

13 (7.9)

3 (1.8)

1 (2.0)

1 (2.0)

MMR Germline Mutation

    

 No

164 (99.4)

124 (75.2)

51 (100.0)

39 (76.5)

 Yes

1 (0.6)

41 (24.8)

0 (0.0)

12 (23.5)

MLH1 Methylation

    

 Unmethylated

159 (96.4)

87 (52.7)

36 (70.6)

23 (45.1)

 Methylated

5 (3.0)

78 (47.3)

1 (2.0)

28 (54.9)

 Unavailable

1 (0.6)

 

14 (27.4)

 

BRAF V600E Mutation

    

 No

146 (88.5)

95 (57.6)

46 (90.2)

25 (49.0)

 Yes

15 (9.1)

66 (40.0)

2 (3.9)

20 (39.2)

 Unavailable

4 (2.4)

4 (2.4)

3 (5.9)

6 (11.8)

CIMP Status

    

 Negative

133 (80.6)

79 (47.9)

  

 Positive

10 (6.1)

63 (38.2)

  

 Unavailable

22 (13.3)

23 (13.9)

51 (100.0)

51 (100.0)

Survival Status

    

 Alive

100 (60.6)‬

99 (60.0)

45 (88.2)

49 (96.1)

 Deceased

65 (39.4)

66 (40.0)

6 (11.8)

2 (3.9)

ITF2 Methylation

    

 Unmethylated

122 (73.9)

95 (57.6)

36 (70.6)

22 (43.1)

 Methylated

43 (26.1)

70 (42.4)

15 (29.4)

29 (56.9)

APC Methylation

    

 Unmethylated

112 (67.9)

103 (67.9)

33 (64.7)

28 (54.9)

 Methylated

53 (32.1)

62 (37.6)

18 (35.3)

23 (45.1)

  1. aStandard Deviation
  2. bProximal tumor location includes lesions up to and including the splenic flexure
  3. cMucinous histology includes the presence of any mucin within the tumor stroma
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