Prognostic value of the distance between the primary tumor and brainstem in the patients with locally advanced nasopharyngeal carcinoma

Table 6 Multivariate analysis of prognostic factors in the patients with locally-advanced nasopharyngeal carcinoma receiving IMRT

End point	Variable	Regression coefficient	Standard error	P-value	Hazard ratio	95 % CI
End point	Variable	Regression coefficient	Standard error	P-value	Hazard ratio	Lower	Upper
OS	Age	0.845	0.252	0.001	2.328	1.422	3.812
	N classification	0.431	0.133	0.001	1.539	1.185	1.999
	Dbs	0.657	0.253	0.010	1.929	1.174	3.170
	T classification	0.383	0.438	0.381	1.467	0.622	3.460
LRFS	Age	1.802	0.578	0.002	6.061	1.953	18.804
	Dbs	1.044	0.518	0.044	2.840	1.030	7.831
	T classification	0.103	0.767	0.894	1.108	0.246	4.986
DMFS	N classification	0.451	0.145	0.002	1.570	1.182	2.085
	Dbs	0.391	0.276	0.156	1.479	0.842	6.638
	T classification	0.958	0.520	0.066	2.606	0.940	7.225
DFS	Age	0.600	0.225	0.008	1.822	1.172	2.835
	N classification	0.344	0.119	0.004	1.411	1.118	1.781
	Dbs	0.682	0.225	0.002	1.977	1.273	3.070
	T classification	0.576	0.403	0.153	1.780	0.808	3.920

Note: Disease staging was according to the 7th edition of the AJCC/UICC staging system
The following parameters were included in the Cox proportional hazards model with backward elimination: Dbs (>4.7 mm vs. ≤ 4.7 mm), age (<50 years vs. ≥ 50 years), gender (female vs. male), World Health Organization (WHO) histological grade (Type II & III vs. Type I), T classification (T3 vs. T4), N classification (N0 vs. N1 vs. N2 vs. N3), chemotherapy (with vs. without), and radiation doses (>73.92 Gy vs. ≤ 73.92 Gy)

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