Table 5 Univariate analysis of prognostic factors in the patients with locally-advanced nasopharyngeal carcinoma receiving IMRT
Variable | No.# N = 346 | 3-year OS (%) | p-value | 3-year LRFS (%) | p-value | 3-year DMFS (%) | p-value | 3-year DFS (%) | p-value |
|---|---|---|---|---|---|---|---|---|---|
Age | 0.003 | <0.001 | 0.305 | 0.015 | |||||
<50 y | 225 | 87.8 | 97.7 | 86.6 | 82.1 | ||||
≥50 y | 121 | 79.0 | 88.1 | 81.5 | 71.6 | ||||
N-stage | 0.003 | 0.904 | <0.001 | 0.018 | |||||
N0 | 63 | 92.0 | 93.5 | 90.1 | 85.6 | ||||
N1 | 110 | 89.0 | 94 | 89.3 | 81.5 | ||||
N2 | 113 | 87.4 | 94.4 | 86.9 | 78.5 | ||||
N3 | 60 | 69.6 | 96.3 | 65.9 | 64.9 | ||||
T-stage | 0.111 | 0.667 | 0.035 | 0.033 | |||||
T3 | 59 | 89.6 | 93.2 | 93.2 | 88.1 | ||||
T4 | 287 | 83.7 | 94.7 | 82.8 | 76.4 | ||||
Overall stage | 0.041 | 0.524 | 0.009 | 0.014 | |||||
III | 53 | 92.3 | 92.5 | 96.2 | 90.6 | ||||
IV | 293 | 83.3 | 94.8 | 82.4 | 76.2 | ||||
Chemotherapy | 0.386 | 0.242 | 0.921 | 0.374 | |||||
Yes | 327 | 85.1 | 94.8 | 84.7 | 79 | ||||
No | 19 | 78.9 | 88.4 | 82.6 | 68.4 | ||||
Cycles of chemotherapy | 0.841 | 0.853 | 0.835 | 0.988 | |||||
<3 | 193 | 84.7 | 94.4 | 85.2 | 79.1 | ||||
≥3 | 153 | 84.8 | 94.5 | 87.0 | 77.6 | ||||
Prescribed dose | 0.926 | 0.509 | 0.832 | 0.981 | |||||
≤73.92 Gy | 311 | 84.7 | 94.2 | 84.5 | 78.0 | ||||
>73.92 Gy | 35 | 85.3 | 96.9 | 85.2 | 82.7 | ||||
GTVnx Dmin | 0.002 | 0.03 | 0.016 | 0.002 | |||||
<66 Gy | 142 | 77.8 | 91.7 | 77.4 | 69.6 | ||||
≥66 Gy | 204 | 89.6 | 96.3 | 89.4 | 84.6 | ||||
Dbs (mm) | 0.007 | 0.018 | 0.067 | 0.002 | |||||
≤4.7 | 136 | 78.4 | 91.1 | 79.3 | 69.6 | ||||
>4.7 | 210 | 88.8 | 96.5 | 87.8 | 84.1 |