|
Age, median (range)
|
62 (24–79)
|
62 (24–76)
|
61 (42–79)
|
0.288
|
|
Sex, n (%)
| | | | |
|
Male
|
63 (80.8)
|
27 (73.0)
|
36 (87.8)
| |
|
Female
|
15 (19.23)
|
10 (27.0)
|
5 (12.2)
|
0.097
|
|
ECOG PS, n (%)
| | | | |
|
0
|
19 (24.4)
|
8 (21.6)
|
11 (26.8)
| |
|
1
|
58 (74.4)
|
28 (75.7)
|
30 (73.2)
| |
|
2
|
1 (1.3)
|
1 (2.7)
|
0 (0.0)
|
0.601*
|
|
Location, n (%)
| | | | |
|
Oropharynx
|
47 (60.3)
|
19 (51.4)
|
28 (68.3)
| |
|
Hypopharynx
|
19 (24.4)
|
11 (29.7)
|
8 (19.5)
| |
|
Larynx
|
3 (3.9)
|
2 (5.4)
|
1 (2.4)
| |
|
Oral cavity
|
5 (6.4)
|
4 (10.8)
|
1 (2.4)
| |
|
Nasal cavity/PNS
|
1 (1.3)
|
0 (0.0)
|
1 (2.4)
| |
|
Others
|
3 (3.9)
|
1 (2.7)
|
2 (4.9)
|
0.364*
|
|
Pathology, n (%)
| | | | |
|
Undifferentiated SCC
|
2 (2.6)
|
2 (5.4)
|
0 (0.0)
| |
|
Poorly differentiated SCC
|
13 (16.7)
|
4 (10.8)
|
9 (22.0)
| |
|
Moderately differentiated SCC
|
20 (25.6)
|
7 (18.9)
|
13 (31.7)
| |
|
Well differentiated SCC
|
7 (9.0)
|
6 (16.2)
|
1 (2.4)
| |
|
Nonkeratinizing carcinoma
|
1 (1.3)
|
1 (2.7)
|
18 (43.9)
| |
|
Unknown/not specified SCC
|
35 (44.9)
|
17 (45.6)
|
0 (0.0)
|
0.058*
|
|
TNM Stage, n (%)
| | | | |
|
III
|
23 (29.5)
|
8 (21.6)
|
15 (36.6)
| |
|
IVA
|
54 (69.2)
|
29 (78.4)
|
25 (61.0)
| |
|
IVB
|
1 (1.3)
|
0 (0.0)
|
1 (2.4)
|
0.140*
|
|
IC, n (%)
|
50 (64.1)
|
25 (67.6)
|
25 (61.0)
| |
|
FP
|
4 (5.1)
|
3 (8.1)
|
1 (2.4)
| |
|
DFP
|
16 (20.5)
|
6 (16.2)
|
10 (24.4)
| |
|
DP
|
26 (33.3)
|
14 (37.8)
|
12 (29.3)
| |
|
DP + cetuximab
|
4 (5.1)
|
2 (5.4)
|
2 (4.9)
|
0.544
|
|
CRT regimen, n (%)
| | | | |
|
Cisplatin
|
71 (91.0)
|
33 (89.2)
|
38 (92.7)
| |
|
Cetuximab
|
3 (3.9)
|
1 (2.7)
|
2 (4.9)
| |
|
Cisplatin + cetuximab
|
3 (3.9)
|
2 (5.4)
|
1 (2.4)
| |
|
Cisplatin + 5-FU
|
1 (1.3)
|
1 (2.7)
|
0 (0.0)
|
0.689*
|
|
Total radiation dose
| | | | |
|
> 60 Gy
|
80 (97.6)
|
38 (97.4)
|
42 (97.7)
| |
|
≤ 60 Gy
|
2 (2.4)
|
1 (2.6)
|
1 (2.3)
|
1.000*
|
|
Failure in six months, n (%)
|
10 (12.8)
|
10 (27.0)
|
0 (0.0)
|
<0.001*
|
|
Locoregional failure alone
|
9 (11.5)
|
9 (24.3)
|
0 (0.0)
| |
|
Systemic & locoregional failure
|
1 (1.3)
|
1 (2.7)
|
0 (0.0)
| |
|
Immediate salvage op, n (%)
|
6 (7.7)
|
6 (16.2)
|
0 (0.0)
|
0.009*
|
