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Table 3 Risk of colorectal cancer in relation to 5 unit change in anthropometric measure by baseline value of the anthropometric measure: Hazard ratios and 95 % CI

From: Change in weight and waist circumference and risk of colorectal cancer: results from the Melbourne Collaborative Cohort Study

  Baseline value of body size a    
  <sex-specific mean value d ≥sex-specific mean value e  
  HR 95 % CI p-value b HR 95 % CI p-value b p-value c
Waist change (per 5 cm) 1.08 [0.97, 1.21] 0.157 0.97 [0.88, 1.07] 0.502 0.01
Weight change (per 5 kg) 1.02 [0.88, 1.18] 0.826 0.88 [0.78, 0.99] 0.038 0.29
Hips change (per 5 cm) 1.04 [0.90, 1.20] 0.595 0.97 [0.86, 1.09] 0.583 0.14
  1. aSex-specific mean of baseline body size: Waist circumference: Males = 94 cm, Females = 80 cm; weight: Males = 81 kg, Females = 68 kg; Hips circumference: Males = 101 cm, Females = 102 cm
  2. b P-value from Cox proportional hazard model adjusted for sex, country of birth, family history of any cancer, quintile of socioeconomic status, baseline body size, cumulative smoking status and physical activity and Mediterranean diet score at baseline and wave 2
  3. c P-value from likelihood ratio test comparing the model with and without the interaction terms; where the interaction term is fitted between the covariate and the exposure of interest (i.e. change variable)
  4. d176 colorectal cancer cases below the sex-specific mean value in 109,725 person-years at risk. Incidence rate = 1.60 per 1,000 person-years (95% CI = 1.38, 1.86)
  5. e197 colorectal cancer cases above the sex-specific mean value in 76,605 person-years at risk. Incidence rate = 2.57 per 1,000 person-years (95% CI = 2.24, 2.96)