| |
Model 1 a
|
Model 2 b
|
|---|
| |
HR
|
95 % CI
|
p-value c
|
HR
|
95 % CI
|
p-value c
|
|---|
|
Colorectal (C18-20) d
| | | | | | |
|
Waist change (per 5 cm)
|
1.00
|
[0.93, 1.08]
|
0.924
|
1.02
|
[0.95, 1.10]
|
0.542
|
|
Weight change (per 5 kg)
|
0.92
|
[0.84, 1.02]
|
0.107
|
0.93
|
[0.85, 1.02]
|
0.147
|
|
Hips change (per 5 cm)
|
0.98
|
[0.90, 1.07]
|
0.654
|
1.01
|
[0.92, 1.10]
|
0.905
|
|
Colon (C18) e
| | | | | | |
|
Waist change (per 5 cm)
|
1.01
|
(0.93, 1.10)
|
0.777
|
1.03
|
(0.95, 1.12)
|
0.444
|
|
Weight change (per 5 kg)
|
0.94
|
(0.84, 1.05)
|
0.278
|
0.95
|
(0.86, 1.05)
|
0.327
|
|
Hips change (per 5 cm)
|
0.96
|
(0.87, 1.07)
|
0.484
|
0.99
|
(0.89, 1.10)
|
0.840
|
|
Rectal (C19,C20) f
| | | | | | |
|
Waist change (per 5 cm)
|
0.98
|
(0.86, 1.11)
|
0.763
|
1.00
|
(0.88, 1.13)
|
0.977
|
|
Weight change (per 5 kg)
|
0.88
|
(0.73, 1.06)
|
0.190
|
0.89
|
(0.75, 1.06)
|
0.191
|
|
Hips change (per 5 cm)
|
1.03
|
(0.88, 1.20)
|
0.747
|
1.05
|
(0.90, 1.22)
|
0.529
|
-
aModel 1: Estimates adjusted for sex and country of birth
-
bModel 2: Estimates adjusted as in model 1, as well as quintile of socioeconomic status, family history of any cancer, body size at baseline, cumulative smoking status, and physical activity and Mediterranean diet score at baseline and wave 2
-
c
P-values from Cox proportional hazard model
-
d373 colorectal cancer cases in 186,329 person-years at risk
- Incidence rate of colorectal cancer = 2.00 per 1,000 person-years (95% CI = 1.81, 2.22)
-
e272 colon cancer cases (C18); Incidence rate = 1.46 per 1,000 person-years (95% CI = 1.30, 1.64)
-
f101 rectal cancer caases (C19,20); Incidence rate = 0.54 per 1,000 person-years (95% CI = 0.45, 0.66)
