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Table 2 Incidence of colorectal cancer in relation to a 5 unit change in anthropometric measure: Hazard ratios and 95 % CI

From: Change in weight and waist circumference and risk of colorectal cancer: results from the Melbourne Collaborative Cohort Study

 

Model 1 a

Model 2 b

 

HR

95 % CI

p-value c

HR

95 % CI

p-value c

Colorectal (C18-20) d

      

Waist change (per 5 cm)

1.00

[0.93, 1.08]

0.924

1.02

[0.95, 1.10]

0.542

Weight change (per 5 kg)

0.92

[0.84, 1.02]

0.107

0.93

[0.85, 1.02]

0.147

Hips change (per 5 cm)

0.98

[0.90, 1.07]

0.654

1.01

[0.92, 1.10]

0.905

Colon (C18) e

      

Waist change (per 5 cm)

1.01

(0.93, 1.10)

0.777

1.03

(0.95, 1.12)

0.444

Weight change (per 5 kg)

0.94

(0.84, 1.05)

0.278

0.95

(0.86, 1.05)

0.327

Hips change (per 5 cm)

0.96

(0.87, 1.07)

0.484

0.99

(0.89, 1.10)

0.840

Rectal (C19,C20) f

      

Waist change (per 5 cm)

0.98

(0.86, 1.11)

0.763

1.00

(0.88, 1.13)

0.977

Weight change (per 5 kg)

0.88

(0.73, 1.06)

0.190

0.89

(0.75, 1.06)

0.191

Hips change (per 5 cm)

1.03

(0.88, 1.20)

0.747

1.05

(0.90, 1.22)

0.529

  1. aModel 1: Estimates adjusted for sex and country of birth
  2. bModel 2: Estimates adjusted as in model 1, as well as quintile of socioeconomic status, family history of any cancer, body size at baseline, cumulative smoking status, and physical activity and Mediterranean diet score at baseline and wave 2
  3. c P-values from Cox proportional hazard model
  4. d373 colorectal cancer cases in 186,329 person-years at risk
  5. Incidence rate of colorectal cancer = 2.00 per 1,000 person-years (95% CI = 1.81, 2.22)
  6. e272 colon cancer cases (C18); Incidence rate = 1.46 per 1,000 person-years (95% CI = 1.30, 1.64)
  7. f101 rectal cancer caases (C19,20); Incidence rate = 0.54 per 1,000 person-years (95% CI = 0.45, 0.66)