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Table 3 Association between CTCs and plasma cytokines

From: CXCR4-SDF-1 interaction potentially mediates trafficking of circulating tumor cells in primary breast cancer

Cytokine Mean SEM Median P-value
IFN-α2 (ng/mL)     
 CTC_EP - 100.52 2.01 98.45 0.002
 CTC_EP+ 116.29 4.84 112.74  
IL-3 (ng/mL)     
 CTC_EP - 40.76 2.90 33.21 0.029
 CTC_EP+ 52.48 6.77 52.83  
MCP-3 (ng/mL)     
 CTC_EP - 53.82 3.53 44.01 0.013
 CTC_EP+ 73.17 8.29 79.21  
β-NGF (ng/mL)     
 CTC_EP - 1.25 0.18 0.86 0.002
 CTC_EP+ 1.52 0.44 1.31  
SCF (ng/mL)     
 CTC_EP - 51.52 2.61 44.74 0.004
 CTC_EP+ 68.62 6.48 69.91  
SCGF-β (ng/mL)     
 CTC_EP - 17377.49 820.65 15565.08 0.008
 CTC_EP+ 22633.38 2029.19 20271.15  
SDF-1α (ng/mL)     
 CTC_EP - 223.75 9.35 219.53 0.036
 CTC_EP+ 265.86 22.85 262.79  
TNF-β (ng/mL)     
 CTC_EP - 0.47 0.04 0.37 0.008
 CTC_EP+ 0.67 0.11 0.71  
CTACK (ng/mL)     
 CTC_EMT - 1394.47 43.93 1343.50 0.046
 CTC_EMT+ 1185.51 110.71 1055.12  
β − NGF (ng/mL)     
 CTC_EMT - 1.38 0.17 0.95 0.046
 CTC_EMT+ 0.77 0.43 0.77  
TRAIL (ng/mL)     
 CTC_EMT - 50.57 2.83 44.37 0.044
 CTC_EMT+ 37.91 7.21 29.28  
TGF-β2 (ng/mL)     
 Any CTC - 2099.93 61.43 2052.98 0.016
 Any CTC+ 2395.52 102.38 2227.53  
  1. Abbreviations: SEM standard error of the mean, CTC_EP – epithelial circulating tumor cells absent, CTC_EP+ epithelial circulating tumor cells absent, CTC_EMT mesenchymal circulating tumor cells absent, CTC_EMT+,– mesenchymal circulating tumor cells present