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Table 3 Association between CTCs and plasma cytokines

From: CXCR4-SDF-1 interaction potentially mediates trafficking of circulating tumor cells in primary breast cancer

Cytokine

Mean

SEM

Median

P-value

IFN-α2 (ng/mL)

    

 CTC_EP -

100.52

2.01

98.45

0.002

 CTC_EP+

116.29

4.84

112.74

 

IL-3 (ng/mL)

    

 CTC_EP -

40.76

2.90

33.21

0.029

 CTC_EP+

52.48

6.77

52.83

 

MCP-3 (ng/mL)

    

 CTC_EP -

53.82

3.53

44.01

0.013

 CTC_EP+

73.17

8.29

79.21

 

β-NGF (ng/mL)

    

 CTC_EP -

1.25

0.18

0.86

0.002

 CTC_EP+

1.52

0.44

1.31

 

SCF (ng/mL)

    

 CTC_EP -

51.52

2.61

44.74

0.004

 CTC_EP+

68.62

6.48

69.91

 

SCGF-β (ng/mL)

    

 CTC_EP -

17377.49

820.65

15565.08

0.008

 CTC_EP+

22633.38

2029.19

20271.15

 

SDF-1α (ng/mL)

    

 CTC_EP -

223.75

9.35

219.53

0.036

 CTC_EP+

265.86

22.85

262.79

 

TNF-β (ng/mL)

    

 CTC_EP -

0.47

0.04

0.37

0.008

 CTC_EP+

0.67

0.11

0.71

 

CTACK (ng/mL)

    

 CTC_EMT -

1394.47

43.93

1343.50

0.046

 CTC_EMT+

1185.51

110.71

1055.12

 

β − NGF (ng/mL)

    

 CTC_EMT -

1.38

0.17

0.95

0.046

 CTC_EMT+

0.77

0.43

0.77

 

TRAIL (ng/mL)

    

 CTC_EMT -

50.57

2.83

44.37

0.044

 CTC_EMT+

37.91

7.21

29.28

 

TGF-β2 (ng/mL)

    

 Any CTC -

2099.93

61.43

2052.98

0.016

 Any CTC+

2395.52

102.38

2227.53

 
  1. Abbreviations: SEM standard error of the mean, CTC_EP – epithelial circulating tumor cells absent, CTC_EP+ epithelial circulating tumor cells absent, CTC_EMT mesenchymal circulating tumor cells absent, CTC_EMT+,– mesenchymal circulating tumor cells present