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Fig. 4 | BMC Cancer

Fig. 4

From: Breast cancer stem cell selectivity of synthetic nanomolar-active salinomycin analogs

Fig. 4

Cell migration after treatment with a 50 nM concentration of salinomycin or salinomycin analogs 2a-c. a Quantification of wound healing. b Representative images of wound healing at 72 h after scratching. c Quantification of migrated cells in a Boyden chamber cell migration assay after 24 h of treatment. d Representative images of migrated cells. JIMT-1 cells were plated in trans wells with membranes containing 8.0 μm pores in medium containing the indicated compound. After 24 h of treatment, cells that had migrated to the bottom of the trans well were stained and photographed. The arrow points to a migrated cell. The small dots are the pores. Data are represented as mean ± SEM for n = 5. Bars in (b) and (d) = 200 μm. SA: salinomycin, 2a: carbamate, 2b: acetate, 2c: carbonate and 3: C1-methyl ester. **P < 0.01 compared to control

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