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Table 1 Binding affinity of ABT-700

From: Anti-c-Met monoclonal antibody ABT-700 breaks oncogene addiction in tumors with MET amplification

 

ABT-700 (nM)

Biding to c-Met protein by ELISAa

0.22

Binding to cellular c-Met by FACSb

 

 A549

0.23

 IM95

0.24

 SNU5

0.55

 EBC1

0.24

 MCF7

No binding

 MCF7-human c-Met

1.3

  1. aEC50 values were derived from an ELISA in which c-Met ECD was captured on the plate via a histidine tag. Value shown is averages of 6 experiments
  2. bEC50 values were derived from FACS analysis of ABT-700 on various cell lines. Values are representative of at least two experiments
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BMC Cancer

ISSN: 1471-2407

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