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Table 1 Characteristics of included studies

From: The combination of blue dye and radioisotope versus radioisotope alone during sentinel lymph node biopsy for breast cancer: a systematic review

Author (year) Design Location Sample size Age Clinical node status NAC use Radioisotope type Blue dye type Site of Blue dye Site of isotope Positive Preo LSG, No. (%)
Bass et al. (1999) [18] NPS USA 700 58 Unknown Unknown Filtered 99mTc-sulfur colloid Isosulfan Intraparenchymal Intraparenchymal Unknown
Mariani et al. (2000) [28] NPS Italy 284 59 Mixed Unknown 99mTc-human albumin Patent blue Subdermal Subdermal Unknown
Rahusen et al. (2000) [30] NPS Netherlands 115 54 Unknown Unknown 99mTc-human albumin Patent blue intradermal Intraparenchymal 105/115 (91 %)
Derossis et al. (2001) [12] NPS USA 2000 Unknown Negative Unknown Unfiltered 99mTc-sulfur colloid Isosulfan Intraparenchymal Intradermal Unknown
Bauer et al. (2002) [19] NPS USA 332 55 Negative Unknown Filtered 99mTc-sulfur colloid Isosulfan Subareolar versus peritumoral Peritumoral 195/223 (87.4 %)
Ahrendt et al. (2002) [17] NPS USA 174 59 Negative Unknown Filtered 99mTc-sulfur colloid Isosulfan Intraparenchymal Intraparenchymal Unknown
Tsunoda et al. (2002) [34] NPS Japan 376 Unknown Mixed No Tin colloid or phytate Unknown Subareolar or peritumoral Peritumoral Unknown
Pelosi et al. (2003) [29] NPS Italy 150 62 NA Unknown 99mTc-labelled Nanocoll Isosulfan Periareolar or subdermal Periareolar or subdermal 93/100 (93 %)
Fleming et al. (2003) [22] NPS Ireland 125 ≈56 Negative Unknown Radiocolloid isotope Isosulfan Periareolar Intraparenchymal versus intradermal 103/125 (82.4 %)
Schirrmeister et al. (2004) [32] NPS Germany 814 58 62.9 % negative Unknown Radioactive colloid Isosulfan or patent blue Optional Optional Unknown
Lauridsen et al. (2004) [24] NPS Denmark 124 56 Negative Unknown 99mTc-human albumin Patent blue Peritumoral Peritumoral Unknown
Mamounas et al. (2005) [27] RCT USA 428 Unknown 76.2 % negative Yes Unknown Isosulfan Unknown Unknown Unknown
Takei et al. (2006) [33] NPS Japan 308 55 Negative Unknown 99mTc-phytate Patent blue Subdermal Subdermal Unknown
Argon et al. (2006) [1] NPS Turkey 100 48 Negative No 99mTc-tin colloid Isosulfan Intraparenchymal Intradermal 90/100 (90 %)
Low et al. (2006) [26] NPS Australia 113 56 Negative Unknown 99mTc-sulfur colloid Patent blue Intradermal or subdermal Peritumoral 97/113 (85.8 %)
Goyal et al. (2006) [23] RCT UK 842 18–80 Negative Unknown 99mTc-albumin colloid Patent blue Peritumoral Peritumoral 490/707 (69.3 %)
Lelievre et al. (2007) [25] NPS France 152 57 Unknown Unknown 99mTc-sulfur colloid Patent blue Subareolar or peritumoral Intradermal and intraparenchymal 149/152 (98 %)
Rodier et al. (2007) [31] RCT France 449 25–90 Negative No 99mTc-sulfur colloid Patent blue Peritumoral versus periareolar Peritumoral versus periareolar 353/432 (81.7 %)
Kang et al. (2010) [10] NPS USA 3402 56 Negative Mixed 99mTc-sulfur colloid Isosulfan Unknown Unknown 1566/1720 (91.0 %)
Johnson et al. (2011) [8] NPS USA 696 57 Unknown Unknown Unfiltered 99mTc- sulfur colloid Isosulfan Subareolar Subareolar Unknown
Kuehn et al. (2013) [3] NPS Germany, Austria 1334 49 Negative Mixed Unknown Unknown Optional Optional 1490/1614 (92.3 %)
Boughey et al. (2013) [20] RCT USA 689 49 (23–93) Positive Yes Unknown Isosulfan or methylene Optional Optional Unknown
Elmadahm et al. (2015) [21] RCT Australia 1088 Unknown Negative No 99mTc-sulfur colloid Patent blue Peritumoural Peritumoural 779/957 (81.4 %)
O'Reilly et al. (2015) [11] RCT Ireland 667 48 Negative No Unknown Isosulfan Intradermal Subdermal 667/667 (100 %)
  1. FNR false-negative rate, LSG lymphoscintigraphy, NAC neoadjuvant chemotherapy, NPS non-randomized prospective study
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