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Table 2 Multivariate cox regression survival analysis

From: Expression and promotor hypermethylation of miR-34a in the various histological subtypes of ovarian cancer

  

PFS

OS

  

HR

CI 95 %

p value

HR

CI 95 %

p value

miR-34a expressionc

high

0.549

[0.31–0.969]

0.039a

0.509

[0.293–0.883]

0.016a

low

1

     

FIGO stage

late

1.646

[0.7–3.871]

0.253

2.058

[0.895–4.727]

0.089

 

early

1

     

Age

>62.3

1.69

[1.017–2.813]

0.043a

2.565

[1.571–4.189]

<0.0001b

 

<62.3

1

     

Residual disease

RD > 0

1.97

[1.057–3.674]

0.033a

2.565

[1.571–4.189]

0.001b

 

RD = 0

1

     

Hystology

d

0.998

[0.773–1.288]

0.987

1.132

[0.886–1.446]

0.321

  

Serous cancers

 
  

PFS

OS

  

HR

CI 95 %

p value

HR

CI 95 %

p value

miR-34a expressionc

high

0.509

[0.227–1.143]

0.102

0.389

[0.173–0.876]

0.022a

low

1

     

FIGO stage

late

2.866

[0.77–10.662]

0.043

2.858

[0.748–10.915]

0.125

 

early

1

     

Age

>62.3

2.304

[1.082–4.905]

0.032

2.925

[1.386–6.174]

0.005

 

<62.3

1

     

Residual disease

RD > 0

1.194

[0.456–3.128]

0.718

1.080

[0.397–2.938]

0.879

 

RD = 0

1

     
  1. asignificant at the 0.05 level (2-tailed). bsignificant at the 0.01 level (2-tailed). carbitrary units normalized to TBP, cut off = 20th centile (0.14)
  2. dserous VS endometrioid VS mucinous VS clear cell