|
Reference
|
Cytotoxic agent
|
Hematotoxicity
|
Pulmonary SE
|
CTH-related deaths (%)
|
|---|
|
CTCAE III/IV (%)
|
CTCAE I - IV (%)
|
|---|
|
Stupp (2005) [1]
|
TMZ (+RT)
|
16
|
-
|
-
|
|
Buckner (2006) [27]
|
BCNU (+ RT)
|
L 28
|
10
|
-
|
|
T 44
|
|
Weller (2003) [45]
|
BCNU (+WBRT)
|
-
|
12
|
4
|
|
Weller (2003) [45]
|
ACNU/VM26 (+RT)
|
36,5
|
0,7
|
2,6
|
|
Brandes (2004) [23]
|
BCNU
|
L 8
| |
ND
|
|
T 10
|
5
|
|
(WHO 3/4)
|
(WHO 4)
|
|
own results
|
BCNU
|
L 1,8
|
0,6
|
0
|
|
T 3,6
|
- SE side effects, CTCAE Common Toxicity Criteria, CTH chemotherapy, L leukopenia, T thrombocytopenia, RT radiotherapy, WBRT whole brain radiotherapy
