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Table 6 BCNU-related side effects - Comparison of own results to the literature

From: Chemotherapy with BCNU in recurrent glioma: Analysis of clinical outcome and side effects in chemotherapy-naïve patients

Reference Cytotoxic agent Hematotoxicity Pulmonary SE CTH-related deaths (%)
CTCAE III/IV (%) CTCAE I - IV (%)
Stupp (2005) [1] TMZ (+RT) 16 - -
Buckner (2006) [27] BCNU (+ RT) L 28 10 -
T 44
Weller (2003) [45] BCNU (+WBRT) - 12 4
Weller (2003) [45] ACNU/VM26 (+RT) 36,5 0,7 2,6
Brandes (2004) [23] BCNU L 8   ND
T 10 5
(WHO 3/4) (WHO 4)
own results BCNU L 1,8 0,6 0
T 3,6
  1. SE side effects, CTCAE Common Toxicity Criteria, CTH chemotherapy, L leukopenia, T thrombocytopenia, RT radiotherapy, WBRT whole brain radiotherapy