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Table 2 Prognostic factors for disease-free survival after colon cancer resection

From: Isolated tumor cells in stage I & II colon cancer patients are associated with significantly worse disease-free and overall survival

Prognostic factors

 

Cox Regression

  

Unadjusted A)

Full model B)

Variable selection C)

  

HR (95 % CI)

p D)

HR (95 % CI)

p D)

HR (95 % CI)

p D)

ITC

No

Reference

0.043

Reference

0.024

Reference

0.005

 

Yes

2.82 (1.06–7.49)

 

3.59 (1.18–10.9)

 

4.73 (1.67–13.4)

 

Age

(years)

1.10 (1.03–1.17)

0.001

1.12 (1.03–1.22)

<0.001

1.13 (1.05–1.21)

<0.001

Gender

male

Reference

0.260

Reference

0.220

-

-

 

female

0.57 (0.21–1.55)

 

0.51 (0.17–1.53)

 

-

-

Tumor localisation

colonic

Reference

0.428

Reference

0.886

-

-

 

rectosigmoidal

0.64 (0.21–2.00)

 

0.91 (0.24–3.47)

 

-

-

AJCC stage

I

Reference

0.569

Reference

0.581

-

-

 

II

1.35 (0.47–3.84)

 

1.39 (0.43–4.52)

 

-

-

Grading

GI/GII

Reference

0.356

Reference

0.952

-

-

 

GIII

1.62 (0.57–4.62)

 

1.04 (0.28–3.84)

 

-

-

Lymphovascular

No

Reference

0.182

Reference

0.368

-

-

invasion

Yes

2.30 (0.74–7.12)

 

2.04 (0.45–9.31)

 

-

-

Preoperative CEA

<5 μg/l

Reference

0.304

Reference

0.302

-

-

levels

≥5 μg/l

0.49 (0.11–2.15)

 

0.42 (0.07–2.44)

 

-

-

TotalLNn

(n)

0.98 (0.94–1.02)

0.323

1.00 (0.95–1.05)

0.898

-

-

SLNn

(n)

1.00 (0.86–1.15)

0.954

1.02 (0.85–1.22)

0.850

-

-

Adjuvant

No

Reference

0.976

Reference

0.705

-

-

Chemotherapy

Yes

0.98 (0.22–4.33)

 

1.47 (0.21–10.4)

 

-

-

  1. HR - Hazard ratios with 95 % confidence intervals (Wald type)
  2. Prognostic factors for overall survival in
  3. A) one Cox proportional hazards regression analyses for each factor
  4. B) Cox proportional hazards regression analyses for all factors
  5. C) Cox proportional hazards regression analyses after backwards variable selection
  6. D) p values for likelihood ratio test