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Table 2 Prognostic factors for disease-free survival after colon cancer resection

From: Isolated tumor cells in stage I & II colon cancer patients are associated with significantly worse disease-free and overall survival

Prognostic factors   Cox Regression
   Unadjusted A) Full model B) Variable selection C)
   HR (95 % CI) p D) HR (95 % CI) p D) HR (95 % CI) p D)
ITC No Reference 0.043 Reference 0.024 Reference 0.005
  Yes 2.82 (1.06–7.49)   3.59 (1.18–10.9)   4.73 (1.67–13.4)  
Age (years) 1.10 (1.03–1.17) 0.001 1.12 (1.03–1.22) <0.001 1.13 (1.05–1.21) <0.001
Gender male Reference 0.260 Reference 0.220 - -
  female 0.57 (0.21–1.55)   0.51 (0.17–1.53)   - -
Tumor localisation colonic Reference 0.428 Reference 0.886 - -
  rectosigmoidal 0.64 (0.21–2.00)   0.91 (0.24–3.47)   - -
AJCC stage I Reference 0.569 Reference 0.581 - -
  II 1.35 (0.47–3.84)   1.39 (0.43–4.52)   - -
Grading GI/GII Reference 0.356 Reference 0.952 - -
  GIII 1.62 (0.57–4.62)   1.04 (0.28–3.84)   - -
Lymphovascular No Reference 0.182 Reference 0.368 - -
invasion Yes 2.30 (0.74–7.12)   2.04 (0.45–9.31)   - -
Preoperative CEA <5 μg/l Reference 0.304 Reference 0.302 - -
levels ≥5 μg/l 0.49 (0.11–2.15)   0.42 (0.07–2.44)   - -
TotalLNn (n) 0.98 (0.94–1.02) 0.323 1.00 (0.95–1.05) 0.898 - -
SLNn (n) 1.00 (0.86–1.15) 0.954 1.02 (0.85–1.22) 0.850 - -
Adjuvant No Reference 0.976 Reference 0.705 - -
Chemotherapy Yes 0.98 (0.22–4.33)   1.47 (0.21–10.4)   - -
  1. HR - Hazard ratios with 95 % confidence intervals (Wald type)
  2. Prognostic factors for overall survival in
  3. A) one Cox proportional hazards regression analyses for each factor
  4. B) Cox proportional hazards regression analyses for all factors
  5. C) Cox proportional hazards regression analyses after backwards variable selection
  6. D) p values for likelihood ratio test