Fig. 1
From: Select Bcl-2 antagonism restores chemotherapy sensitivity in high-risk neuroblastoma
Bcl-2 dependent NB cell lines are sensitive to ABT-199 in vitro. Bcl-2 dependent cell lines SMS-SAN (a), NB-1643 (b) were exposed to ABT-737 or ABT-199 at given concentrations for 48 h and then evaluated for survival by WST-1. Mcl-1 dependent (c) IMR5 was completely resistant to Bcl-2 antagonism. Values statistically significant from 0 nM control are denoted with stars as follows: (*) p ≤ 0.05, (**) p ≤ 0.01, (***) p ≤ 0.001, (****) p ≤ 0.0001, as determined by student’s t test