Fig. 1
From: Distinct genomic and epigenomic features demarcate hypomethylated blocks in colon cancer
Analysis pipeline. Starting with ~13,000 HMBs, we perform a number of tests to assess the association of HMBs and HMB boundaries with Topological Associating Domains, Physical interaction within and across HMBs, profiles of various epigenetic marks, and CTCF binding. In addition, we identified TF motifs enriched at the HMB boundaries relative to various controls and assessed the ability of a random forest model to distinguish HMB boundaries from other domains based on TF binding site motifs. Finally, we assessed the spatial profile and functions of enriched TF motifs and their interacting partners