Table 3 Diagnostic performance for PCa of the most significant urine-gene expression signatures containing PCA3 gene, reported originally and validated in our cohort
Study | Biomarkers | Initial performance reported | Performance validation (our cohort) | ||||||
|---|---|---|---|---|---|---|---|---|---|
n total (T/C) | SN (%) | SP (%) | AUC | n total (T/C) | SN (%) | SP (%) | AUC | ||
Hessels et al., 2003 [4] | PCA3 | 108 (24/84) | 67 | 83 | 0.717 | 224 (151/73) | 49 | 85 | 0.708 |
Hessels et al., 2007 [9] | PCA3, TMPRSS2:ERG | 108 (78/30) | 73 | 52 | - | 224 (151/73) | 48 | 86 | 0.708 |
Laxman et al., 2008 [10] | PCA3, TMPRSS2:ERG, GOLPH2, SPINK1 | 234 (138/96) | 66 | 76 | 0.758 | 224 (151/73) | 72 | 64 | 0.719 |
Ouyang et al., 2009 [11] | PCA3, AMACAR | 92 (43/49) | 81 | 53 | - | 224 (151/73) | 48 | 85 | 0.707 |
Rigau et al., 2010 [12] | PCA3, PSGR | 215 (73/142) | 77 | 60 | 0.73 | 224 (151/73) | 62 | 71 | 0.708 |
Present study, 2015 | HIST1H2BG, SPP1, ELF3 and PCA3 | 224 (151/73) | 77 | 83 | 0.763 | 224 (151/73) | 77 | 83 | 0.763 |