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Table 2 Univariate logistic regression and ROC analyses of the biomarkers

From: Using gene expression from urine sediment to diagnose prostate cancer: development of a new multiplex mRNA urine test and validation of current biomarkers

Variable Fold change Univariate logistic regression analysis ROC analysis
OR (95 % CI) p value AUC (95 % CI)
PCA3 1.331 4.106 (7.534–2.237) <0.01* 0.708 (0.742–0.675)
ELF3 −1.676 0.637 (0.818–0.496) <0.01* 0.657 (0.693–0.621)
MYO6 −1.270 0.561 (0.826–0.381) 0.003* 0.622 (0.659–0.585)
HIST1H2BG −1.243 0.609 (0.852–0.435) 0.004* 0.613 (0.65–0.575)
GALNT3 −1.064 0.556 (0.955–0.324) 0.033* 0.583 (0.622–0.545)
PHF12 −1.074 0.68 (0.982–0.471) 0.04* 0.567 (0.606–0.528)
GDF15 −1.240 0.681 (0.995–0.466) 0.047* 0.594 (0.632–0.556)
PTOV1 −1.110 0.615 (1.028–0.368) 0.063 0.592 (0.63–0.554)
PSMA 1.108 1.99 (4.153–0.954) 0.067 0.59 (0.628–0.552)
SPINK1 −1.156 0.74 (1.046–0.524) 0.089 0.572 (0.611–0.534)
SOX4 −1.148 0.663 (1.065–0.413) 0.089 0.571 (0.61–0.533)
KLK12 −1.142 0.639 (1.091–0.375) 0.101 0.577 (0.615–0.538)
SLC44A5 −1.090 0.646 (1.122–0.372) 0.121 0.57 (0.609–0.532)
SPP1 1.241 1.126 (1.335–0.95) 0.171 0.543 (0.582–0.504)
DLX1 −1.169 0.718 (1.16–0.444) 0.175 0.562 (0.601–0.523)
CTHRC1 −1.178 0.724 (1.157–0.453) 0.177 0.556 (0.595–0.518)
TOX3 −1.057 0.677 (1.198–0.383) 0.18 0.56 (0.599–0.522)
TRPM4 −1.130 0.69 (1.217–0.391) 0.2 0.554 (0.592–0.515)
ELAVL2 −1.068 0.734 (1.186–0.454) 0.207 0.554 (0.593–0.515)
TWIST1 −1.120 0.744 (1.19–0.466) 0.217 0.558 (0.6–0.52)
  1. Abbreviations: OD odds ratio, 95 % CI 95 % confidence interval, AUC Area Under the Curve
  2. *Statistically significant (p < 0.05)
  3. Note: Only biomarkers presenting a p value < 0.25 are listed. Univariate logistic regression and ROC analysis for all biomarkers is shown in Additional file 2: Table S2