|
Variable
|
Fold change
|
Univariate logistic regression analysis
|
ROC analysis
|
|---|
|
OR (95 % CI)
|
p value
|
AUC (95 % CI)
|
|---|
|
PCA3
|
1.331
|
4.106 (7.534–2.237)
|
<0.01*
|
0.708 (0.742–0.675)
|
|
ELF3
|
−1.676
|
0.637 (0.818–0.496)
|
<0.01*
|
0.657 (0.693–0.621)
|
|
MYO6
|
−1.270
|
0.561 (0.826–0.381)
|
0.003*
|
0.622 (0.659–0.585)
|
|
HIST1H2BG
|
−1.243
|
0.609 (0.852–0.435)
|
0.004*
|
0.613 (0.65–0.575)
|
|
GALNT3
|
−1.064
|
0.556 (0.955–0.324)
|
0.033*
|
0.583 (0.622–0.545)
|
|
PHF12
|
−1.074
|
0.68 (0.982–0.471)
|
0.04*
|
0.567 (0.606–0.528)
|
|
GDF15
|
−1.240
|
0.681 (0.995–0.466)
|
0.047*
|
0.594 (0.632–0.556)
|
|
PTOV1
|
−1.110
|
0.615 (1.028–0.368)
|
0.063
|
0.592 (0.63–0.554)
|
|
PSMA
|
1.108
|
1.99 (4.153–0.954)
|
0.067
|
0.59 (0.628–0.552)
|
|
SPINK1
|
−1.156
|
0.74 (1.046–0.524)
|
0.089
|
0.572 (0.611–0.534)
|
|
SOX4
|
−1.148
|
0.663 (1.065–0.413)
|
0.089
|
0.571 (0.61–0.533)
|
|
KLK12
|
−1.142
|
0.639 (1.091–0.375)
|
0.101
|
0.577 (0.615–0.538)
|
|
SLC44A5
|
−1.090
|
0.646 (1.122–0.372)
|
0.121
|
0.57 (0.609–0.532)
|
|
SPP1
|
1.241
|
1.126 (1.335–0.95)
|
0.171
|
0.543 (0.582–0.504)
|
|
DLX1
|
−1.169
|
0.718 (1.16–0.444)
|
0.175
|
0.562 (0.601–0.523)
|
|
CTHRC1
|
−1.178
|
0.724 (1.157–0.453)
|
0.177
|
0.556 (0.595–0.518)
|
|
TOX3
|
−1.057
|
0.677 (1.198–0.383)
|
0.18
|
0.56 (0.599–0.522)
|
|
TRPM4
|
−1.130
|
0.69 (1.217–0.391)
|
0.2
|
0.554 (0.592–0.515)
|
|
ELAVL2
|
−1.068
|
0.734 (1.186–0.454)
|
0.207
|
0.554 (0.593–0.515)
|
|
TWIST1
|
−1.120
|
0.744 (1.19–0.466)
|
0.217
|
0.558 (0.6–0.52)
|
- Abbreviations: OD odds ratio, 95 % CI 95 % confidence interval, AUC Area Under the Curve
- *Statistically significant (p < 0.05)
- Note: Only biomarkers presenting a p value < 0.25 are listed. Univariate logistic regression and ROC analysis for all biomarkers is shown in Additional file 2: Table S2
