Table 4 The cross-neutralization pattern of immunized mice sera after different L-asparaginase administration, IgG-response

EcA

GMT

2.2 (0.2–19.2)

2.6 (0.2–38.4)

6.9 (0.3–184.0)

6.6 (0.2–176.2)

p

0.935

0.875

0.413

0.432

WsA

GMT

52.3 (2.8–979.2)

6.9 (0.3–184.0)

5.7 (0.3–115.3)

10.5 (0.7–149.6)

p

0.029

0.437

0.521

0.277

YpA

GMT

659.8 (178.9–2433.6)

362.4 (77.0–1705.7)

165.7 (3.3–8296.3)

50.0 (50.0–50.0)

p

<0.001

<0.001

<0.001

0.003

RrA

GMT

4.7 (0.0–663.9)

No response

125.0 (125.0–125.0)

7.1 (0.2–257.2)

p

0.475

0.002

0.284

EwA

GMT

148.7 (85.6–258.0)

No response

7.1 (0.2–257.2)

8.9 (0.2–514.8)

p

<0.001

0.201

0.135