Fig. 5

Analytical methods to asses cell proliferation and cell death in response to FAC treatment. a 3D representation of morphologic examination, EdU incorporation and TUNEL analysis per individual tumor. For every tumor the dilution at which a threshold was observed was plotted for each analytical method. Most sensitive tumors cluster in the upper most front part of the graph and most resistant tumors cluster at the lower back side of the 3D graph. Red box represents the resistant tumors based on arbitrary limits. b Scatterplots comparing two analytical methods for therapy response. For every tumor the dilution at which a threshold was observed was plotted for each analytical method. The resistant tumors based on arbitrary limits are outlined in red