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Fig. 4 | BMC Cancer

Fig. 4

From: Evaluation of TgH(CX3CR1-EGFP) mice implanted with mCherry-GL261 cells as an in vivo model for morphometrical analysis of glioma-microglia interaction

Fig. 4

Observation of microglial and tumor cells reveals morphological changes in the core during gliomagenesis. a–r Time-course of glioma growth in mouse brain implanted with mCherry-GL261 cells 3, 6, 9, 12, 14 and 18 days after mCherry-GL261 injection in adult TgH(CX3CR1-EGFP) mice shown as maximum intensity projections of the tumor core. Channels are represented by endogenous fluorescence of EGFP in microglia (left column), mCherry in GL261 glioma cells (middle column) and merge (right column). As shown in K and L (red arrow), a polykaryocyte cell appeared at 12 dpi. Scale bar: 20 μm

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