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Fig. 1 | BMC Cancer

Fig. 1

From: Evaluation of TgH(CX3CR1-EGFP) mice implanted with mCherry-GL261 cells as an in vivo model for morphometrical analysis of glioma-microglia interaction

Fig. 1

Epifluorescence imaging (a) 3, (b) 6 and (c) 18 dpi reveals tumor growth and metastasis. Coronal sections of a TgH(CX3CR1-EGFP) mouse brain implanted with mCherry-GL261 cells. a and d Glioma cells infiltrated the cortex and surrounding areas; red arrow (a) points to a secondary tumor in the left ventricle. Injection site three dpi of mCherry-GL261 cells, showing an intense microgliosis around the tumor tissue. b and e red arrows (b) point to secondary tumors in the right ventricle. Microglial infiltration in tumor core 6 days after injection, while microgliosis remained present in tumor border. c and f An enlarged and diffuse mass of glioma cells developed 18 dpi, including metastasis in the hypothalamus (red outlined arrow, c). Epifluorescence imaging in (a, b and c), confocal microscopy of the region indicated by white boxes in (a–c) in (d, e and f). Scale bars: (a–c), 500 μm; (d–f), 100 μm

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