Inflammatory biomarker score and cancer: A population-based prospective cohort study

BMC Cancer

Table 2 Hazard Ratios (HR) and 95 % Confidence Intervals (CI) of cancer risk by quartiles of biomarkers and z-score

	Q1	Q2	Q3	Q4	P-trend
Leukocyte Count
No of Cases/Total	157/672	146/638	170/630	180/630
Age-adjusted	1.0 (ref)	1.02 (0.82-1.28)	1.29 (1.03-1.60)	1.64 (1.32-2.03)	0.01
Multivariable¹	1.0 (ref)	1.01 (0.80-1.26)	1.24 (0.99-1.54)	1.56 (1.25-1.94)	0.02
Multivariable²	1.0 (ref)	0.97 (0.77-1.22)	1.15 (0.92-1.43)	1.31 (1.04-1.66)	0.19
C-reactive protein
No of Cases/Total	151/639	168/643	163/645	171/643
Age-adjusted	1.0 (ref)	1.13 (0.90-1.40)	1.22 (0.97-1.52)	1.49 (1.20-1.86)	0.01
Multivariable¹	1.0 (ref)	1.09 (0.88-1.37)	1.17 (0.93-1.46)	1.37 (1.09-1.72)	0.05
Multivariable²	1.0 (ref)	1.08 (0.87-1.35)	1.11 (0.88-1.39)	1.23 (0.97-1.55)	0.18
Z-score³
No of Cases/Total	139/642	163/643	168/643	183/642
Multivariable²	1.0 (ref)	1.18 (0.94-1.49)	1.26 (1.00-1.59)	1.47 (1.16-1.88)	<0.01

¹Multivariable model adjusted for age, examination year, alcohol intake, cardiorespiratory fitness and energy intake
²Multivariable model adjusted for age, examination year, alcohol intake, cardiorespiratory fitness, energy intake and smoking
³Z-score was computed for each participant based on the subject’s biomarker levels (x), study mean (μ) and study standard deviation (σ)
We computed the individual z-scores thus; z-score = (x - μ)/σ. The combined z-score is the sum of the subject’s individual CRP and leukocyte z-scores

ISSN: 1471-2407