Table 1 Clinical pathological features of the 59 GIST cases according to DOG1 expression

Sex

 Male, n (%)

31 (52.5 %)

19 (48.7 %)

12 (60 %)

p = 0.413

 Female, n (%)

28 (47.5 %)

20 (51.3 %)

8 (40 %)

Age (years)

 Mean (±SD)

63.3 (±14.6)

63.1 (±16.9)

63.6 (±12.8)

p = 0.8973

 Median

67

65

66.5

 Range

28–88

28–88

34–82

Primary site

p = 0.0652

 Stomach

39 (66.1 %)

29 (74.3 %)

10 (50 %)

 Small intestine

12 (20.3 %)

8 (20.5 %)

4 (20 %)

 Large bowel

4 (6.8 %)

1 (2.6 %)

3 (15 %)

 Others

4 (6.8 %)

1 (2.6 %)

3 (15 %)

Tumor size (cm)

p = 0.0002

 Mean (±SD)

8.3 (±5.5)

10.1 (±5.8)

4.7 (±1.9)

 Median

6

8

4.7

 Range

2–20

3–20

2–10

Histological subtype

p = 0.2

 Spindle type

45 (76.3 %)

27 (69.2 %)

18 (90 %)

 Epithelial type

6 (10.2 %)

5 (12.8 %)

1 (5 %)

 Mixed type

8 (13.5 %)

7 (18 %)

1 (5 %)

Mitoses per 50 HPFs

 ≤ 5

25 (42.4 %)

15 (38.5 %)

10 (50 %)

p = 0.54

 6–10

17 (28.8 %)

13 (33.3 %)

4 (20 %)

 ≥ 10

17 (28.8 %)

11 (28.2 %)

6 (30 %)

Mutated exon

  KIT exon 11

30 (56.6 %)

24 (68.6 %)

6 (33.5 %)

p = 1

  KIT exon 9

2 (3.8 %)

2 (5.7 %)

0

  KIT exon 13

2 (3.8 %)

2 (5.7 %)

0

  KIT exon 17

1 (1.9 %)

0

1 (5.5 %)

  PDGFRA exon 12

1 (1.9 %)

0

1 (5.5 %)

p = 0.889

  PDGFRA exon 18

3 (5.6 %)

2 (5.7 %)

1 (5.5 %)

 Wild type

14 (26.4 %)

5 (14.3 %)

9 (50 %)

p = 0.009

 Not available

6

4

2