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Table 4 SPM risk associated with combined FAS/FASL variant genotypes after index OPC and non-OPC, stratified by smoking and alcohol

From: Site disparities in apoptotic variants as predictors of risk for second primary malignancy in patients with squamous cell carcinoma of the head and neck

Variables Low-risk groupa High-risk groupb cHRsc, (95 % CI), P aHRsd (95 % CI), P
No. % No. % Low-risk group (ref.) vs. High-risk group Low-risk group (ref.) vs. High-risk group
 OPC 575 76.5 177 23.5   
  Smoking       
  Ever 325 56.5 104 58.8 1.4 (0.5–3.3), 0.722 1.4 (0.6–3.4), 0.787
 Never 250 43.5 73 41.2 18.9 (1.3–330.2), 0.032 20.0 (1.2–327.0), 0.028
 Alcohol       
  Ever 421 73.2 128 72.3 1.3 (0.3–3.7), 0.823 1.4 (0.5–3.8), 0.822
  Never 154 26.8 49 27.7 1.9 (0.3–17.2), 0.887 1.8 (0.2–16.1), 0.867
Non-OPC 614 79.0 163 21.0   
 Smoking       
  Ever 455 74.1 125 76.7 2.1 (1.1–4.2), 0.013 2.3 (1.2–4.4), 0.011
  Never 159 25.9 38 23.3 0.2 (0.1–1.4), 0.346 0.1 (0.0–1.2), 0.323
  Alcohol       
  Ever 426 69.4 124 76.1 2.3 (1.1–3.9), 0.022 2.2 (1.2–4.1), 0.019
  Never 188 30.6 39 23.9 0.5 (0.2–4.3), 0.798 0.6 (0.1–4.1), 0.801
  1. aLow-risk group: 0–2 variant genotypes
  2. bHigh-risk group: 3–4 variant genotypes
  3. cCrude HRs
  4. dHRs were adjusted for age, sex, ethnicity, smoking, alcohol, index cancer stage, and treatment