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Table 4 SPM risk associated with combined FAS/FASL variant genotypes after index OPC and non-OPC, stratified by smoking and alcohol

From: Site disparities in apoptotic variants as predictors of risk for second primary malignancy in patients with squamous cell carcinoma of the head and neck

Variables

Low-risk groupa

High-risk groupb

cHRsc, (95 % CI), P

aHRsd (95 % CI), P

No.

%

No.

%

Low-risk group (ref.) vs. High-risk group

Low-risk group (ref.) vs. High-risk group

 OPC

575

76.5

177

23.5

  

  Smoking

      

  Ever

325

56.5

104

58.8

1.4 (0.5–3.3), 0.722

1.4 (0.6–3.4), 0.787

 Never

250

43.5

73

41.2

18.9 (1.3–330.2), 0.032

20.0 (1.2–327.0), 0.028

 Alcohol

      

  Ever

421

73.2

128

72.3

1.3 (0.3–3.7), 0.823

1.4 (0.5–3.8), 0.822

  Never

154

26.8

49

27.7

1.9 (0.3–17.2), 0.887

1.8 (0.2–16.1), 0.867

Non-OPC

614

79.0

163

21.0

  

 Smoking

      

  Ever

455

74.1

125

76.7

2.1 (1.1–4.2), 0.013

2.3 (1.2–4.4), 0.011

  Never

159

25.9

38

23.3

0.2 (0.1–1.4), 0.346

0.1 (0.0–1.2), 0.323

  Alcohol

      

  Ever

426

69.4

124

76.1

2.3 (1.1–3.9), 0.022

2.2 (1.2–4.1), 0.019

  Never

188

30.6

39

23.9

0.5 (0.2–4.3), 0.798

0.6 (0.1–4.1), 0.801

  1. aLow-risk group: 0–2 variant genotypes
  2. bHigh-risk group: 3–4 variant genotypes
  3. cCrude HRs
  4. dHRs were adjusted for age, sex, ethnicity, smoking, alcohol, index cancer stage, and treatment