Skip to main content

Advertisement

Fig. 2 | BMC Cancer

Fig. 2

From: Regulation of the tumour suppressor PDCD4 by miR-499 and miR-21 in oropharyngeal cancers

Fig. 2

a Expression levels of PDCD4, miR-21 and miR-499 in tonsil SCC tissue normalized to expression in adjacent healthy tissue (10 patients were analyzed in this cohort). b Panel i) Representative staining of PDCD4 in normal epithelium with a 3+ scoring intensity. Panel ii) PDCD4 staining in Tonsil SCC tissue with a 3+ scoring intensity. Panel iii) PDCD4 staining in Tonsil SCC tissue with a 2+ scoring intensity. Panel iv) negative PDCD4 staining in Tonsil SCC tissue. c Summary of PDCD4 expression in tonsil cohort (+ to +++, with three + being high expression). d Reduction of miR-21 levels using a LNA anti-sense in SCC089 cell lines. Expression of miR-21 was then normalized to the LNA antisense scramble control. e PDCD4 mRNA levels in miR-21 depleted cells normalized against the LNA antisense scramble control. f Protein Expression of PDCD4 in miR-21 depleted SCC089 and HEK-293 cells

Back to article page