Fig. 1
From: Regulation of the tumour suppressor PDCD4 by miR-499 and miR-21 in oropharyngeal cancers
a Heatmap showing two class-SAM analyses for differentially expressed miRNAs in tonsil cancers. Green bar: normal samples, red bar: SCC samples. miRNA genes shown in yellow and blue represent up-regulated and down-regulated, respectively. b Validation of miR-372, miR-499, miR-21 and let7c in the Australian patient cohort (n = 10). Each miRNA was determined in the tumor tissue with fold expression normalized to paired normal tissue. c Validation of let-7c, miR-21 and miR-499 was performed using a second UK patient cohort. d Expression of the miRNA biogenesis machinery in 10 paired tonsil SCC samples. Expression of each gene was determined in the tumor tissue and then normalized to the paired normal tissue