HOX transcription factors are potential targets and markers in malignant mesothelioma

BMC Cancer

Table 1 HOX genes with potential oncogenic or tumor suppressor functions

Gene	O / S	Evidence	Reference
HOXA1	O	Transforms non-malignant mammary epithelial cells	[28]
HOXA9	O	Key oncogene in leukemia	[29]
HOXB3	O	Pro-survival and proliferation gene in leukemia	[29]
HOXB4	O	Pro-survival and proliferation gene in leukemia	[29]
HOXB5	O	Transfection can immortalize fibroblast cells	[21]
HOXB6	O	Transfection can immortalize myelomonocytic cells	[10]
HOXB9	O	Promotes tumorogenesis in breast cancer	[30]
HOXC4	O	High expression in malignant prostate cells	[31]
HOXA4	S	Blocks spread of ovarian cancer cells	[32]
HOXA5	S	Identified as a tumor suppressor gene in breast ca	[9]
HOXC8	S	Expression inversely related to progression	[33]
HOXC12	S	Promotes cell differentiation in follicular lymphoma	[22]
HOXD12	S	Silenced in melanoma cells	[23]

O HOX gene with oncogenic activity, S HOX gene with tumor suppressor activity

ISSN: 1471-2407