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Fig. 2 | BMC Cancer

Fig. 2

From: HOX transcription factors are potential targets and markers in malignant mesothelioma

Fig. 2

HXR9 is cytotoxic in mesothelioma-derived cell lines. a Fluorescent micrograph of NCI-H28 cells treated with 18 μM FITC-HXR9 (green) showing uptake into the nucleus and cytoplasm. Cell nuclei are stained blue. Scale bar: 5 μm. b Sample dose response curves for HXR9 and CXR9 treatment of NCI-H28 and Met-5A cell lines. c IC50 values for HXR9 in mesothelioma-derived cell lines. All incubations with HXR9 were for 2 h. Each value is the mean of five experiments, error bars show the SEM. The NCI-H28, MSTO-211H, and NCI-H2052 cells were all significantly more sensitive to killing by HXR9 than Met-5a (**, p < 0.01; ***, p < 0.001)

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