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Table 1 Transcripts up- or down-regulated in transgelin cDNA-transfected RKO cells

From: Transgelin increases metastatic potential of colorectal cancer cells in vivo and alters expression of genes involved in cell motility

Rank

Symbol

Gene name

Fold up

P value

Function

1

HOOK1

Hook homolog 1

95.7

0.011

actin binding

2

SDCCAG8

serologically defined colon cancer antigen 8

85.8

0.023

microtubule organizing center

3

ENAH

enabled homolog

17.7

0.045

actin binding

4

TNS1

Tensin 1

14.3

0.014

actin binding

5

ST8SIA4

ST8 alpha-N-acetyl-neuraminide alpha-2, 8-sialyltransferase 4

13.2

0.047

sialyltransferase activity

6

ARHGAP29

Rho GTPase activating protein 29

13.0

0.046

GTPase activator activity

7

FBXL14

F-box and leucine-rich repeat protein 14

11.3

0.005

protein binding

8

ZNF704

zinc finger protein 704

10.5

0.020

zinc ion binding

9

CCDC141

coiled-coil domain containing 141

8.7

0.036

protein binding

10

SPECC1

sperm antigen with calponin homology and coiled-coil domains 1

8.2

0.020

cell adhesion

Rank

Symbol

Gene name

Fold down

P value

Function

1

EMB

embigin

15.9

0.005

cell adhesion

2

WIPF1

WAS/WASL interacting protein family, member 1

13.0

0.006

actin binding

3

BCL11B

B-cell CLL/lymphoma 11B (zinc finger protein)

12.0

0.0004

nucleic acid binding

4

IL15

interleukin 15

11.3

0.010

signal transducer activity

5

PTPRD

protein tyrosine phosphatase, receptor type, D

11.0

0.021

phosphoprotein phosphatase

6

FRRS1

ferric-chelate reductase 1

10.4

0.004

ferric-chelate reductase

7

INSM1

insulinoma-associated 1

10.1

0.045

nucleic acid binding

8

PTGIS

prostaglandin I2 (prostacyclin) synthase

9.8

0.006

monooxygenase

9

PDGFB

platelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog)

9.8

0.004

PDGF receptor binding

10

POU3F1

POU class 3 home box 1

8.7

0.005

DNA binding

  1. Gene expression profiling was performed on RKO cell populations that were stably transfected with empty control vector or with transgelin cDNA expression vector. Experiment was performed using Affymetrix microarray technology as described in Methods. P values have been adjusted for multiple testing