Table 2 Relative quantification of mRNA expression (fold change) in tumour sample subsets stratified by histology, stage, sex and smoking history

MYCN

n = 170

n = 94

n = 44

n = 32

n = 94

n = 54

n = 22

n = 91

n = 79

n = 11

n = 54

n = 105

median

0.43

0.46

0.54

0.24

0.517

0.46

0.38

0.40

0.723

0.47

0.37

0.057

1.12

0.47

0.37

0.195

(range)

(0.01–943.85)

(0.03–943.85)

(0.02–10.25)

(0.01–43.00)

(0.02–88.53)

(0.01–166.37)

(0.32–943.85)

(0.01–943.85)

(0.03–166.37)

(0.20–13.55)

(0.01–88.53)

(0.03–943.85)

HMGA2

n = 132

n = 71

n = 36

n = 25

n = 70

n = 41

n = 21

n = 79

n = 53

n = 8

n = 44

n = 80

median

20.01

13.12

70.65

5.77

0.003**

15.33

40.88

7.58

0.360

17.33

23.16

0.758

18.28

29.14

16.98

0.945

(range)

(0.21–33877.07)

(0.56–2736.65)

(0.71–33877.07)

(0.21–10749.96)

(0.21–13499.32)

(0.27–33877.07)

(0.31–2168.39)

(0.27–33877.07)

(0.21–13499.32)

(2.67–640.82)

(0.21–13499.33)

(0.31–33877.07)

CDKN2A

n = 171

n = 96

n = 44

n = 31

n = 95

n = 53

n = 23

n = 93

n = 78

n = 10

n = 55

n = 106

median

4.94

4.93

4.85

6.55

0.777

4.93

5.18

5.48

0.811

3.77

8.40

0.013*,**

5.25

4.48

5.31

0.505

(range)

(0.07–7818.30)

(0.08–7818.30)

(0.21–333.40)

(0.07–193.94)

(0.07–7818.30)

(0.08–193.94)

(0.19–156.38)

(0.07–193.94)

(0.43–7818.30)

(2.17–179.05)

(0.07–7818.30)

(0.08–333.40)

DICER1

n = 164

n = 93

n = 40

n = 31

n = 87

n = 54

n = 23

n = 89

n = 75

n = 11

n = 51

n = 102

median

0.99

0.91

1.00

1.25

0.304

1.03

0.90

0.88

0.550

1.01

0.87

0.763

1.68

0.95

0.89

0.698

(range)

(0.21–119.51)

(0.24–119.51)

(0.21–7.76)

(0.25–5.07)

(0.21–45.80)

(0.25–119.51)

(0.27–5.70)

(0.21–7.76)

(0.24–119.51)

(0.27–2.23)

(0.21–45.80)

(0.25–119.51)