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Table 2 Relative quantification of mRNA expression (fold change) in tumour sample subsets stratified by histology, stage, sex and smoking history

From: The MYCN-HMGA2-CDKN2A pathway in non-small cell lung carcinoma—differences in histological subtypes

Genes All Histology Stage Sex Smoking history
   AC SCC Other p-value I II III p-value Male Female p-value Never Former Current p-value
MYCN n = 170 n = 94 n = 44 n = 32   n = 94 n = 54 n = 22   n = 91 n = 79   n = 11 n = 54 n = 105  
median 0.43 0.46 0.54 0.24 0.517 0.46 0.38 0.40 0.723 0.47 0.37 0.057 1.12 0.47 0.37 0.195
(range) (0.01–943.85) (0.03–943.85) (0.02–10.25) (0.01–43.00)   (0.02–88.53) (0.01–166.37) (0.32–943.85)   (0.01–943.85) (0.03–166.37)   (0.20–13.55) (0.01–88.53) (0.03–943.85)  
HMGA2 n = 132 n = 71 n = 36 n = 25   n = 70 n = 41 n = 21   n = 79 n = 53   n = 8 n = 44 n = 80  
median 20.01 13.12 70.65 5.77 0.003** 15.33 40.88 7.58 0.360 17.33 23.16 0.758 18.28 29.14 16.98 0.945
(range) (0.21–33877.07) (0.56–2736.65) (0.71–33877.07) (0.21–10749.96)   (0.21–13499.32) (0.27–33877.07) (0.31–2168.39)   (0.27–33877.07) (0.21–13499.32)   (2.67–640.82) (0.21–13499.33) (0.31–33877.07)  
CDKN2A n = 171 n = 96 n = 44 n = 31   n = 95 n = 53 n = 23   n = 93 n = 78   n = 10 n = 55 n = 106  
median 4.94 4.93 4.85 6.55 0.777 4.93 5.18 5.48 0.811 3.77 8.40 0.013*,** 5.25 4.48 5.31 0.505
(range) (0.07–7818.30) (0.08–7818.30) (0.21–333.40) (0.07–193.94)   (0.07–7818.30) (0.08–193.94) (0.19–156.38)   (0.07–193.94) (0.43–7818.30)   (2.17–179.05) (0.07–7818.30) (0.08–333.40)  
DICER1 n = 164 n = 93 n = 40 n = 31   n = 87 n = 54 n = 23   n = 89 n = 75   n = 11 n = 51 n = 102  
median 0.99 0.91 1.00 1.25 0.304 1.03 0.90 0.88 0.550 1.01 0.87 0.763 1.68 0.95 0.89 0.698
(range) (0.21–119.51) (0.24–119.51) (0.21–7.76) (0.25–5.07)   (0.21–45.80) (0.25–119.51) (0.27–5.70)   (0.21–7.76) (0.24–119.51)   (0.27–2.23) (0.21–45.80) (0.25–119.51)  
  1. AC adenocarcinoma, SCC squamous cell carcinoma, *p-value < 0.05 Mann–Whitney U test. **p-value < 0.05 Kruskal-Wallis test