Fig. 1From: The MYCN-HMGA2-CDKN2A pathway in non-small cell lung carcinoma—differences in histological subtypesThe MYCN, HMGA2, CDKN2A pathway. MYCN functions as a positive regulator of LIN28B, a known repressor of the let-7 family of microRNAs via binding to DICER1. Loss of let-7 microRNAs can lead to HMGA2 overexpression that may result in a downregulation of CDKN2ABack to article page