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Table 2 Foetal and placental parameters in Walker tumour-bearing rats and ascitic fluid-injected rats fed either a control or leucine-rich diet

From: Dietary leucine supplementation minimises tumour-induced damage in placental tissues of pregnant, tumour-bearing rats

  C W A L LW LA Interaction effectb Tumour effectb Diet effectb
Foetal resorption per dam 0.900±0.314 3.300±0.538* 2.500±0.562* 0.889±0.309 1.600±0.499 1.700±0.473 P = 0.0321 P = 0.0043 n.s.
Foetal weight (g) 3.92 ± 0.07 2.73 ± 0.20* 2.61 ± 0.05* 3.65 ± 0.06 2.85 ± 0.08* 2.96 ± 0.09* n.s. P < 0.0001 n.s.
Placenta weight (g) 0.48 ± 0.01 0.53 ± 0.02 0.42 ± 0.02 0.52 ± 0.03 0.52 ± 0.01 0.50 ± 0.02 n.s. n.s. n.s.
Placental protein content (μg/mg) 7.38 ± 0.48 3.81 ± 0.29* 4.70 ± 0.34* 7.14 ± 0.28 6.87 ± 0.56 6.37 ± 0.67 P = 0.0043 P = 0.0002 n.s.
Placental DNA (μg/mg) 0.46 ± 0.02 0.38 ± 0.02* 0.38 ± 0.02* 0.46 ± 0.03 0.49 ± 0.02 0.43 ± 0.04 n.s. P = 0.0052 n.s.
Placental protein/DNA ratioa 16.8 ± 1.2 11.5 ± 0.9* 14.2 ± 1.5 17.3 ± 1.1 15.4 ± 1.5 17.3 ± 2.5 P = 0.0212 P = 0.0311 n.s.
  1. Caption: Control (C), Leucine (L), Walker tumour-bearing rats (W), tumour-bearing rats subjected to a leucine-rich diet (LW), rats inoculated with ascitic fluid (A), and rats inoculated with ascitic fluid and subjected to a leucine-rich (LA). The results are expressed as the mean and standard deviation. *P < 0.05 compared with the control group. aPlacental protein/DNA ratio was used as an index of cell size. b Significant difference accounted by tumour, diet or interaction effect, analysed by two-way ANOVA with Bonferroni testing, n.s. = non-significant