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Table 3 Stability and rate of metastasis of tumors implanted at different positionsa

From: Establishment and characterization of a metastasis model of human gastric cancer in nude mice

Variable No Growth in implanted position (%) Metastasis retroperitoneum (%) Viscera (%) Generation time (days)
Passage number      
 1st 5 100 (5/5) 100 (5/5) 80 (4/5) 20
 2nd 5 100 (5/5) 80 (4/5) 100 (5/5) 14
 3rd 5 100 (5/5) 100 (5/5) 80 (4/5) 14
 4th 5 100 (5/5) 80 (4/5) 100 (5/5) 15
 5th 5 100 (5/5) 100 (5/5) 80 (4/5) 14
 6th 5 100 (5/5) 80 (4/5) 100 (5/5) 13
 7th 5 100 (5/5) 100 (5/5) 100 (5/5) 17
 8th 5 100 (5/5) 100 (5/5) 100 (5/5) 18
 9th 5 100 (5/5) 100 (5/5) 100 (5/5) 17
 10th 5 100 (5/5) 100 (5/5) 100 (5/5) 18
Stored in liquid nitrogen      
 4th 5 100 (5/5) 100 (5/5) 100 (5/5) 17
 8th 5 100 (5/5) 100 (5/5) 100 (5/5) 18
Implantation in different position      
 Groins 50 100 (50/50) 94 (47/50) 94 (47/50) 16
 Back 10 100 (10/10) 30 (3/10) 10 (1/10) 20
 Armpits 10 100 (10/10) 0 (0/10) 30 (3/10) 14
  1. a After ten generations of implantation, all mice developed tumor growth at the implanted position, and 94 % of mice developed metastasis to the retroperitoneum and viscera, regardless whether the tumor source was fresh or frozen. The average time of bearing tumor is 16 days. The groin of mice is best Implantation position, resulting in 94 % retroperitoneum and viscera metastasis