Histological analyses | |||||
Subgroup | SOS | Moderate/Severe SOS | Hepatic fibrosis | Hepatic steatosis | |
Total | - | 0.50 [0.37, 0.67] | 0.25 [0.17, 0.38]; | 0.61 [0.44, 0.86] | 0.96 [0.63, 1.45] |
p < 0.001; I2 = 0 % | p < 0.001; I2 = 0 % | p =0.004; I2 = 7 % | p = 0.83; I2 = 30 % | ||
No of BEV cycles | ≤6 | 0.50 [0.34, 0.72] | 0.21 [0.11, 0.41] | 0.60 [0.38, 0.94] | 0.94 [0.56, 1.59] |
p < 0.001; I2 = 0 % | p < 0.001; I2 = 0 % | p = 0.03; I2 = 0 % | p = 0.82; I2 = 53 % | ||
>6 | 0.46 [0.21, 1.01] | 0.29 [0.10, 0.81] | 0.43 [0.19, 1.0] | 0.93 [0.34, 2.52] | |
p = 0.05; I2 = 0 % | p = 0.02; I2 = 0 %a | p = 0.05; I2 = 0 %b | p = 0.89; I2 = 31 % | ||
Time last BEV cycle to surgery | ≤8 weeks | 0.47 [0.23, 0.95] | 0.21 [0.10, 0.47] | - | - |
p = 0.04; I2 = 32 % | p < 0.001; I2 = 0 % | ||||
>8 weeks | 0.50 [0.28, 0.86] | 0.26 [0.12, 0.56] | 0.61 [0.34, 1.09] | 0.63 [0.21, 1.84] | |
p = 0.01; I2 = 0 % | p < 0.001; I2 = 0 % | p = 0.09; I2 = 0 % | p = 0.39; I2 = 45 % | ||
Cytotoxic chemotherapy4 | Oxaliplatin high | 0.46 [0.21, 1.01] | 0.29 [0.10, 0.81] | 0.43 [0.19, 1.00] | 0.93 [0.34, 2.52] |
p = 0.05; I2 = 0 % | p = 0.02; I2 = 0 %a | p = 0.05; I2 = 0 %b | p = 0.89; I2 = 31 % | ||
Oxaliplatin low | 0.51 [0.37, 0.69] | 0.25 [0.16, 0.38] | 0.52 [0.37, 0.75] | 0.94 [0.56, 1.59] | |
p < 0.001; I2 = 0 % | p < 0.001; I2 = 0 % | p < 0.001; I2 = 0 % | p = 0.82; I2 = 53 % | ||
Functional Recovery and Perioperative Outcome | |||||
Morbidity | Wound complications | Liver failure | Mortality | ||
Total | - | 1.10 [0.88, 1.37] | 1.81 [1.12, 2.91] | 0.61 [0.34, 1.07] | 0.60 [0.20, 1.82] |
p = 0.39; I2 = 10 % | p = 0.02; I2 = 4 % | p = 0.08; I2 = 6 % | p = 0.37; I2 = 0 % | ||
No of BEV cycles | ≤6 | 0.99 [0.75, 1.30] | 1.22 [0.61, 2.42] | 0.49 [0.21, 1.14] | 0.54 [0.10, 2.93] |
p = 0.95; I2 = 0 % | p = 0.58; I2 = 0 %c | p = 0.10; I2 = 0 % | p = 0.47; I2 = 0 % | ||
>6 | 1.51 [1.08, 2.13] | 1.88 [0.89, 3.99] | 0.85 [0.36, 2.00] | 0.46 [0.09, 2.41] | |
p = 0.02; I2 = 0 % | p = 0.10; I2 = 0 % | p = 0.71; I2 = 16 % | p = 0.36; I2 = 0 % | ||
Time last BEV cycle to surgery | ≤8 weeks | 1.06 [0.70, 1.59] | 1.59 [0.50, 5.11] | 0.50 [0.16, 1.57] | 1.16 [0.14, 9.37] |
p = 0.80; I2 = 33 % | p = 0.43; I2 = 0 % | p = 0.24; I2 = 0 % | p = 0.89; I2 = 0 % | ||
>8 weeks | 1.27 [0.92, 1.74] | 1.45 [0.84, 2.50] | 0.70 [0.32, 1.51] | 0.47 [0.13, 1.71] | |
p = 0.15; I2 = 0 % | p = 0.19; I2 = 0 % | p = 0.36; I2 = 23 % | p = 0.25; I2 = 0 % | ||
Cytotoxic chemotherapyd | Oxaliplatin high | 1.19 [0.87, 1.63] | 1.47 [0.87, 2.49] | 0.61 [0.28, 1.30] | 0.55 [0.14, 2.19] |
p = 0.28; I2 = 17 % | p = 0.15; I2 = 0 % | p = 0.20; I2 = 29 % | p = 0.40; I2 = 0 % | ||
Oxaliplatin low | 1.01 [0.74, 1.38] | 3.19 [0.82, 12.35] | 0.50 [0.16, 1.59] | 0.70 [0.11, 4.47] | |
p = 0.95; I2 = 6 % | p = 0.09; I2 = 51 % | p = 0.24; I2 = 0 % | p = 0.71; I2 = 0 % |