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Table 1 Characteristics of identified studies

From: Impact of Bevacizumab on parenchymal damage and functional recovery of the liver in patients with colorectal liver metastases

Reference Year Inclusion period Sample size (total/BEV) Study type CTX in BEV group OX/IRI/OX + IRI [%] No BEV cycles Interval last BEV cycle to surgery Risk of bias
Aussilhou 2009 2002–2008 40/13 Prosp. CS 54/38 12 (2–36) 92 days High
Constantinidou 2013 Until 9/2010 94/42 Retrosp. CS 64/33 4.5 (4–12)a 73 (44–141) days High
D’Angelica 2007 2004–2005 64/32 Matched CCS 56/37 9 (4–15) 6.9 (3–15) weeks High
Kesmodel 2008 2004–2006 125/81 Retrosp. CS 70/36 84 (14–513)b 58 (31–117) days High
Klinger 2009 2001–2006 106/56 Retrosp. CSe 100/0 5 5 weeks High
Lubezky 2013 2000–2007 191/134 Retrosp. CS 72/28 - >6 weeks High
Mahfud 2010 2005–2007 90/45 Matched CCS 24/71 9 (7–10)a 9 weeks (60, 47–73 days) Low
Millet 2012 2006–2011 82/41 Matched CCS 15/85 6 (4–16)a 65 (39–90) days Low
Pessaux 2010 2005–2007 42/21 Matched CCS 76/10/14 8.1 ± 4.7 11.7 ± 4.7 weeks Low
Reddy 2008 1996–2006 96/39 Retrosp. CS 79/21 6 (3–8)c 10 (8–13) weeks High
Ribero 2007 2002–2006 105/62 Retrosp. CS 100/0 6 (3–12)a >6 weeks High
Rong 2014 2002–2012 501/117 Retrosp. CS 100/0 6 ± 12a - High
Rubbia Brandt 2010 274/70d Retrosp. CS 100/0 - - High
Tamandl 2009 2005–2009 214/102 Retrosp. CS 82/13 6 (1–20) 34 (17–99) days High
van der Pool 2012 2003–2008 104/51 Retrosp. CS 100/0 4 (1–15)a 11 (5–38) weeks High
Vera 2014 2005–2011 95/51 Retrosp. CS 45/53 6 (1–21)a - High
Wicherts 2011 2005–2009 164/67 Retrosp. CS 23/68/2 8.6 (1–34) 8 (3–19) weeks Low
Zorzi 2008 1995–2007 43/26 Retrosp. CS 100/0 5 (3–20)a 7.9 (3–36) weeks High
  1. aNumber of CTx cycles
  2. bDuration of BEV treatment in days
  3. cDuration of BEV treatment in months
  4. dIrinotecan was added in 79 patients of the whole study cohort
  5. eCombined retrospective analysis of two phase II trials. Continuous data are presented as median (range) or mean (standard deviation) based on the kind of data presented in the original publication
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