Table 4 Expression of TGF-β signaling molecules according to Lauren’s classification
Intestinal-type | Diffuse-type | P-value | ||
|---|---|---|---|---|
(n = 33) | (n = 35) | |||
TGF-β1 | Low | 13 | 23 | 0.050 |
High | 20 (61 %) | 12 (34 %) | ||
TβR2 | Low | 0 | 12 | <0.001 |
High | 33 (100 %) | 23 (66 %) | ||
Smad4 | Low | 23 | 25 | 0.588 |
High | 8 (26 %) | 9 (27 %) | ||
p-ERK1/2 | Low | 3 | 12 | 0.008 |
High | 14 (82 %) | 7 (37 %) | ||
p-Akt | Low | 9 | 11 | 0.796 |
High | 23 (72 %) | 24 (69 %) | ||
TAK1 | Low | 4 | 6 | 0.758 |
High | 27 (87 %) | 29 (84 %) |