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Table 1 Patient demographics

From: Systemic inflammation is an independent predictive marker of clinical outcomes in mucosal squamous cell carcinoma of the head and neck in oropharyngeal and non-oropharyngeal patients

Characteristic All patients (N = 145)a Oropharyngeal (n = 76)a Non-oropharyngeal (n = 69)a p value*
Age, median years (range) 63 (28–86) 59.5 (32–83) 67 (28–86) <0.01
Sex, n (%)     0.5
 Male 115 (79) 62 (82) 53 (77)  
 Female 30 (21) 14 (18) 16 (23)  
ECOG PS, n (%)     <0.001
 0 102 (70) 64 (84) 38 (55)  
 1 32 (22) 10 (13) 22 (32)  
 2 10 (7) 2 (3) 8 (12)  
 Missing 1 (1) - 1 (1)  
Smoking status, n (%)     0.2
 Non-smoker 44 (30) 24 (32) 20 (29)  
 Ex-smoker 61 (42) 36 (47) 25 (36)  
 Current smoker 37 (26) 15 (20) 22 (32)  
 Missing 3 (2) 1 (1) 2 (3)  
Tumour site, n (%)     <0.001
 Lip and oral cavity 25 (17) 0 (0) 25 (36)  
 Nasopharynx 8 (6) 0 (0) 8 (12)  
 Oropharynx 76 (52) 76 (100) 0 (0)  
 Hypopharynx 12 (8) 0 (0) 12 (17)  
 Larynx 24 (17) 0 (0) 24 (35)  
Tumour stage, n (%)     0.05
 T1 35 (24) 24 (32) 11 (16)  
 T2 52 (36) 29 (38) 23 (33)  
 T3 36 (25) 15 (19) 21 (30)  
 T4 22 (15) 8 (11) 14 (20)  
Nodal stage, n (%)     <0.001
 N0 44 (30) 11 (14) 33 (48)  
 N1 36 (25) 22 (29) 14 (20)  
 N2 60 (41) 41 (54) 19 (28)  
 N3 5 (3) 2 (3) 3 (4)  
AJCC stage, n (%)     0.2
 I 9 (6) 4 (5) 5 (7)  
 II 35 (24) 18 (24) 17 (25)  
 III 74 (51) 44 (58) 30 (43)  
 IV 27 (19) 10 (13) 17 (27)  
p16 tumour status, n (%)     <0.001
 Negative 48 (51) 7 (16) 41 (80)  
 Positive 47 (49) 37 (84) 10 (20)  
 Missing 50 32 19  
Treatment, n (%)     <0.001
 Radiotherapy 17 (12) 10 (13) 7 (10)  
 Postoperative radiotherapy 29 (20) 3 (4) 26 (38)  
 Chemoradiotherapy 88 (61) 61 (80) 27 (39)  
 Postoperative chemoradiotherapy 11 (8) 2 (3) 9 (13)  
 Neutrophils, median counts (range) x 109 cells/L 5.10 (1.10 - 11.90) 4.60 (1.10 - 11.90) 5.30 (2.10 - 11.80) 0.2
 Lymphocytes, median counts (range) x 109 cells/L 1.60 (0.20 - 10.70) 1.60 (0.40 - 3.40) 1.70 (0.20 - 10.70) 0.1
 NLR, median counts (range) x 109 cells/L 3.11 (0.41 - 29.75) 3.11 (1.30 - 29.75) 3.11 (0.41 - 16.00) 0.9
NLR, n (%)     0.7
 Low (≤5) 116 (80) 60 (79) 56 (81)  
 High (>5) 29 (20) 16 (21) 13 (19)  
  1. Abbreviations: ECOG PS Eastern Cooperative Oncology Group performance status, AJCC American Joint Committee on Cancer and NLR neutrophil-to-lymphocyte ratio
  2. *, appropriate statistical test (Students t-test, Mann Whitney-U, χ2 test or Fishers exact test) conducted between oropharyngeal and non-oropharyngeal cancer patient excluding missing values and a, missing values indicated in table