Table 4 Comparative performance of CDRUG (existing method) and our models based on potency score, SVM and hybrid approach
Method | Sensitivity | Specificity | Accuracy | MCC | FPR | AUC |
|---|---|---|---|---|---|---|
CDRUG | 65 | - | - | - | 0.05 | 0.88 |
74 | Â | Â | Â | 0.10 | ||
81 | - | - | - | 0.20 | ||
Potency Score | 65.8 | 98.9 | 83.5 | 0.7 | 0.02 | 0.95 |
74.26 | 98.42 | 87.15 | 0.76 | 0.02 | ||
84.62 | 96.45 | 90.94 | 0.82 | 0.05 | ||
SVM | 65.47 | 98.66 | 83.34 | 0.69 | 0.02 | 0.95 |
74.16 | 97.63 | 86.8 | 0.75 | 0.03 | ||
89.02 | 91.52 | 90.42 | 0.81 | 0.09 | ||
Hybrid | 65.57 | 99.63 | 83.75 | 0.71 | 0.01 | 0.98 |
74.41 | 99.11 | 87.59 | 0.77 | 0.01 | ||
92.38 | 92.55 | 92.47 | 0.85 | 0.08 |