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Fig. 6 | BMC Cancer

Fig. 6

From: Aspirin inhibits epithelial-to-mesenchymal transition and migration of oncogenic K-ras-expressing non-small cell lung carcinoma cells by down-regulating E-cadherin repressor Slug

Fig. 6

Schematic illustration depicts the potential role of aspirin in reprogramming EMT in oncogenic K-ras-expressing NSCLC cells. Left panel demonstrates the conjoint role of K-ras and NFκB pathways in up-regulation of Slug transcription towards EMT in NSCLC cells. Right panel shows aspirin-mediated inhibition of EMT and migration of NSCLC cells through inhibition of p65NFκB nuclear translocation that resulted in down-regulation of Slug, a transcriptional repressor of E-cadherin

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