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Fig. 5 | BMC Cancer

Fig. 5

From: Aspirin inhibits epithelial-to-mesenchymal transition and migration of oncogenic K-ras-expressing non-small cell lung carcinoma cells by down-regulating E-cadherin repressor Slug

Fig. 5

Aspirin retards p65NFκB-nuclear translocation to ensure Slug down-regulation. a Western blot analysis to determine p-IκBα and total p65NFκB expression levels in untreated and aspirin treated-A549 cells. b Protein expression levels of p65NFκB in nuclear and cytosolic lysates of untreated and aspirin treated-A549 cells as determined by western blot assay. c ChIP assay for p65NFκB binding on the SLUG promoter 1 (upper panel) and 2 (lower panel) in untreated and aspirin treated-A549 cells. α-Actin/ Histone H1 served as loading controls. Data are presented as mean ± SEM or representative of three independent experiments

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