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Table 1 Pathophysiological and clinical differences in radiation dermatitis with RT/CRT and cetuximab + RT

From: Asian expert recommendation on management of skin and mucosal effects of radiation, with or without the addition of cetuximab or chemotherapy, in treatment of head and neck squamous cell carcinoma

RT/CRT alone Cetuximab + RT
Pathophysiological (for more details, please refer to text)
Clinical
Onset of dermatitis is within 3–5+ weeks of treatment Onset of dermatitis is within 1 or 2 weeks of treatment
No crusting Crusting is present, which can result in sustained microtrauma, bleeding, and discomfort and can lead to infection
  1. # Images courtesy of Dr. Merlano